Cancer Guidelines Database

Access quality cancer guidelines from a single Canadian source

We've listed 151 guidelines under your selection of "Location". The most recent guidelines are first.

Influenza Immunization for Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult and pediatric patients with cancer. The guideline examines influenza immunization in these patients, including recommended vaccine, dosing, as well as the effect of age, duration, and systemic therapy on the patient's response to the vaccination. Patients undergoing hematopoietic stem cell transplant (HSCT) are further discussed, as is the immunization of individuals in contact with these patients.

Cancer Pain

Year: 2018
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with active cancer. The guideline examines screening, assessment, and management strategies for cancer-related pain of any severity in these patients. Pharmacological management options discussed include acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs), adjuvant analgesics, opioid drugs, and management of cancer pain in patients with renal impairment. Non-pharmacological management options including radiotherapy, vertebroplasty and kyphoplasty, anesthetic interventions, surgical interventions, and complementary therapies are also discussed. The guideline also considers supportive care of these patients.

Chronic Lymphocytic Leukemia

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with chronic lymphocytic leukemia. The guideline examines the diagnostic and staging criteria, treatment strategies, and follow-up and supportive care practices for these patients. First and second line treatment options are discussed for newly diagnosed, relapsed, and refractory disease.

Acute Myeloid Leukemia

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with acute myeloid leukemia (AML). The guideline examines the diagnostic criteria and prognostic markers of acute myeloid leukemias. Different management options for acute myeloid leukemia are discussed, including chemotherapy, hematopoietic stem cell transplantation, and palliation.

Lymphoma

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients who have been diagnosed with or are suspected of having lymphoma. The guideline discusses Hodgkin lymphoma, as well as the most common non-Hodgkin lymphomas (T-cell and B-cell). Recommendations are provided on diagnosis, staging, treatment, management, and follow up care.

Local Prostate Cancer

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult men with a suspicion or recent diagnosis of localized prostate cancer. The guideline examines staging, treatment options, and follow-up for these patients. Management is discussed for low, intermediate, and high-risk disease. Treatment options considered include variations of radical prostatectomy, brachytherapy, external beam radiotherapy, cryosurgery, and active surveillance.

Advanced / Metastatic Prostate Cancer

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients who have been diagnosed with or are suspected of having advanced/metastatic prostate cancer. The guideline provides guidance on the staging, treatment, and follow up procedures for these patients. Topics of interest include radiotherapy techniques, the use of bone scans to assist in staging, and follow-up using active surveillance within a cancer clinic.

Metastatic Colorectal Cancer

Year: 2018
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with metastatic colorectal cancer. The guideline examines treatment options, including different chemotherapy regimens, and metastasectomy. Other topics of discussion include palliative chemotherapy regimens, and treatment of liver metastasis. Outcomes of interest include adverse effects, overall survival, and quality of life.

Breast Reconstruction Following Prophylactic or Therapeutic Mastectomy for Breast Cancer

Year: 2017
AGREE II score: Available
Developer organization: Alberta Health Services
This clinical practice guideline provides recommendations for breast reconstruction in women following mastectomy for the prevention or treatment of breast cancer. The guideline discusses patient education, eligibility for reconstruction, timing of reconstruction, factors that enhance recovery from reconstruction, post-reconstruction surveillance, and measuring outcomes of construction. The benefits and risks of implant-based, autologous flap, and combination reconstruction procedures are examined. The guideline also discusses the extent to appropriately perform mastectomy.

Cancer-Related Fatigue

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with cancer-related fatigue. The guideline examines the appropriate screening, assessment, and management of these patients. Interventions discussed include pharmacological management, physical activity, functional and occupational therapy interventions, psychosocial and educational interventions, complementary therapies, nutrition, and management of anemia. Recommendations are provided based on the severity of fatigue.

Prophylaxis and Treatment of Venous Thrombemolism in Patients Undergoing Treatment for Solid Tumours

Year: 2017
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline discussing the treatment and prophylaxis of venous thromboembolism (VTE) in patients receiving treatment for solid (i.e. non-hematologic) tumours. The guideline examines the pharmacologic therapy and dosing options for both inpatients and ambulatory patients with established VTE or who are at risk for VTE (i.e. prophylaxis). The guideline also discusses common complications associated with antithrombotic therapy, as well as the follow-up of patients during its administration.

Pneumococcal Immunization in Adult and Pedtric Patients Undergoing Cancer Treatment

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline on pneumococcal immunization for adult and pediatric cancer patients with solid tumours or hematologic cancers. The guideline provides recommendations on the type of vaccine and timing of immunization in relation to the type of treatment, therapy cycle, and severity of immunosuppression. Guidance is also provided on restrictions for immunization.

Desmoid Tumours

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with desmoid tumours. The guideline provides recommendations for diagnosis, staging procedures, treatment, and follow-up. Treatment options including active surveillance, surgery, radiation therapy, and chemotherapy are examined. Topics of interest include desmoid tumours occurring during pregnancy, pain management, and rehabilitation.

Soft-Tissue Sarcoma: Management of Metastatic Disease

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with soft-tissue sarcoma who are being considered for chemotherapy. The guideline provides recommendations for staging procedures and classifications, as well as treatment options based on staging results and other risk factors. Treatment options including surgery, systemic therapy, radiation therapy, and chemotherapy are discussed. Outcomes of interest include adverse events, performance status, progression-free survival, and overall survival.

Management of Chronic Myeloid Leukemia 

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline on the diagnosis, staging, treatment and management of adult patients who are suspected of having, or have been diagnosed with, chronic myelogenous leukemia (CML). Treatment options examined include the use of tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, dasatinib, bosutinib, and ponatinib, as well as allogeneic stem cell transplant (SCT) and Interferon-a (IFNa). Special consideration is paid to the use of TKIs in the treatment of elderly patients with CML.

Oral and Dental Care Management in Head and Neck Cancer

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with head and neck cancer. The guideline examines oral and dental care assessment and management of patients before, during, and after cancer treatment. Topics addressed include pain, xerostomia, speech and swallowing disorders, oral hygiene, and functional capacity. The primary outcome of interest is quality of life.

Renal Cell Carcinoma

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with renal cell carcinoma (RCC). The guideline examines the clinical management of RCC, including diagnosis, treatment, and follow up. The primary outcomes of interest are survival, recurrence, and quality of life.

Hepatocellular Carcinoma

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with hepatocellular carcinoma (HCC). The guideline examines the goals of therapy, and provides recommendations for the treatment of patients with different stages of HCC, from very early stages to terminal stage. Outcomes of interest include rendering the patient free of disease, preventing recurrence, and improving quality of life.

Adenocarcinoma of the Pancreas

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the management of adult patients with adenocarcinoma of the pancreas. The guideline provides recommendations on diagnostic work-up, staging, and treatment options based on stage of cancer. Specific topics discussed include management recommendations for unresectable adenocarcinoma, and toxicity-associated dose modification. Outcomes of interest include adverse events, overall survival, and quality of life.

Early Stage Colon Cancer

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with early stage colon cancer. The guideline discusses diagnostic work-up, staging, and treatment options. Recommendations for adjuvant chemotherapy are presented, based on cancer stage.

Brain Oligometastases

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with four or fewer brain metastases. The guideline examines the important prognostic factors for assessing and managing these patients, the role of surgery and radiotherapy in the management of oligometastatic disease, and the appropriate follow-up and surveillance strategy. Treatments considered include whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS), both alone and in conjunction.

Stereotactic Radiosurgery: Benign Indications

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with benign brain tumors. The guideline examines the appropriateness of stereotactic radiosurgery for treating these patients, as well as the appropriate dose for stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT). Recommendations are provided for benign brain tumors that can be treated with stereotactic radiotherapy, including vestibular schwannoma, pituitary adenomas, meningiomas, and other indications such as craniopharyngiomas and hemangioblastomas.

Influenza Immunization for Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2017
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline discussing influenza immunization for adult and pediatric cancer patients. The guideline provides guidance on the timing of influenza immunization in relation to severity of immunosuppression and chemotherapy schedules, number of administrations, types of influenza vaccines, and contraindications and precautions for immunization. Recommendations for the immunization of family members and hospital or clinic staff are also provided.

Testicular Germ Cell Tumours

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with testicular germ cell tumours (GCTs). The guideline examines appropriate management and follow-up strategies for different stages of the two main histological types of testicular GCTs: seminomas and nonseminomas. Outcomes of interest include recurrence and overall survival.

Metastatic Colorectal Cancer

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the treatment of adult patients with metastatic colorectal cancer. The guideline examines different management options, including treatment via clinical trials, treatment chemotherapy, palliative chemotherapy, EGFR inhibitors, and regorafenib (as a fourth-line therapy). The guideline also discusses the need to test for Ras mutations before treatment. Outcomes of interest include treatment efficacy and improved survival outcomes.

Malignant Biliary Obstruction

Year: 2016
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with neoplasms causing biliary obstruction. The guideline examines the management of malignant biliary obstructions, including diagnostic work-up and treatment options. Recommendations are provided based on factors such as the resectability and location of the obstruction. Outcomes of interest include improved quality of life (QOL) and prolonged survival.

Adjuvant Systemic Therapy for Early Stage (Lymph Node Negative and Lymph Node Positive) Breast Cancer

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline examines adjuvant systemic therapy for early stage breast cancer. The guideline provides a systematic method for treatment decision-making for patients with lymph node negative breast cancer and lymph node positive breast cancer, based on level of risk and hormone receptor status. The guideline further explores chemotherapy options for these patients and considers the influence of menopausal status on treatment decisions.

Low-Grade Gliomas

Year: 2016
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with low-grade gliomas (LGGs). The guideline examines the diagnosis, prognosis, and treatment of these patients. Treatment modalities discussed include surgery, radiation therapy, and chemotherapy.

Management Of Fluorouracil (5-Flourouracil, 5Fu) Infusion Overdose Guideline

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A guideline for the management of fluorouracil for treating solid tumours. The guideline examines the safe management of fluorouracil in medication pumps, and recommendations for treating and monitoring patients who have overdosed. Important aspects include specific dosing regimens, fluid administration calculations, and outpatient management.

Tobacco Screening and Treatment for Adult Cancer Patients

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults (aged 18 and older) at any phase of the cancer care continuum regardless of cancer type, stage (including metastatic) or treatment plan, with some components of the guideline also applicable to the patient's family and/or caregivers. Recommendations are provided on implementation of the brief tobacco intervention using the evidence-based AAR Brief Tobacco Intervention Model which includes screening, education and assessment, treatment plan, and referral, monitoring, and follow-up. The 2015 guideline was revised in June 2016 to abbreviate the cessation intervention model to best support adoption across all CCA clinics and settings. Clinical considerations and contraindications of treatment options for cancer patients are discussed including nicotine replace therapy (NRT), bupropion, varenicline, and e-cigarettes, and the impact of tobacco use on cancer treatment is reviewed with a specific focus on erlotinib and irinotecan.

Pneumococcal Immunization for Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult and pediatric patients with cancer, including hematological cancers and solid tumours. The guideline examines pneumococcal immunization in order to prevent secondary infections. Outcomes of interest include reduced pneumonial mortality and improved immunization scheduling.

Influenza Immunization For Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline provides recommendations on influenza vaccinations for children and adults with solid tumours or hematologic malignancies. Recommendations are provided for vaccine type (live versus inactivated) and administration in relation to the therapy cycle, and are stratified by patient age (adult versus pediatric). Topics of discussion include the effects of age, duration, and type of systemic therapy in regards to response of patients to the influenza vaccine, as well as contraindications and precautions for immunization.

Gastrointestinal Stromal Tumours (GIST)

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with gastrointestinal stromal tumours. The guideline examines appropriate imaging modalities, and treatment for newly diagnosed and metastatic tumours. Outcomes of interest include disease progression and recommended imaging.

Palliative Radiotherapy: Bleeding and Gastrointestinal Obstruction

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for palliative oncology patients 18 years of age or older with low grade/ low volume/ malignancy-associated urogenital or gastrointestinal bleeding, or with malignant gastrointestinal obstruction, compression or invasion. External beam radiotherapy (EBRT) with or without , brachytherapy, stent placement, and surgical bypass are discussed as therapeutic options. Outcomes of interest include clinical improvement of symptoms, quality of life, and survival.

Lymphoma

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline addressing lymphoma in the adult population. The guideline focuses on diagnosis and pathology, staging, and treatment of Non-Hodgkin Lymphomas, Hodgkin Lymphoma, HDCT and hematopoietic stem cell transplantation for lymphoma. Supportive and follow-up care is also addressed. The guideline updates the 2015 guideline of the same title.

Chronic Lymphocytic Leukemia

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult patients with chronic lymphocytic leukemia. The guideline examines diagnosis, staging, and treatment of newly diagnosed, relapsed, and refractory leukemia. Outcomes of interest include progression-free survival, reduced adverse events, and treatment response.

Acute Lymphoblastic Leukemia

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the diagnosis and treatment of acute lymphoblastic leukemia in adult and pediatric patients. The guideline examines diagnostic methods, treatment by age group, and special considerations including allogeneic stem cell transplantation and the role of cranial radiation. Outcomes of interest include probability of survival and incidence of hematological relapse.

Palliative Radiotherapy: Bone Metastases and Spinal Cord Compression

Year: 2016
AGREE II score: Available
Developer organization: Alberta Health Services
A clinical practice guideline for patients with bone metastases and spinal compression as common causes of cancer-related pain. The guideline examines radiotherapy and prophylactic steroids to reduce pain and pain flares. Outcomes of interest include improved neurological outcomes, survival, and reduced functional interference.

Palliative Radiotherapy: Superior Vena Cava Obstruction, Dyspnea, and Hemoptysis

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
The guideline provides recommendations for management and treatment of patients 18 years of age and older who have malignant superior vena cava obstruction (SVCO) or airway obstruction, compression, or invasion, or those experiencing hemoptysis. The course of management is dependent on symptoms, primary histology, urgency of histology, previous treatment, and access to resources. External beam radiotherapy (EBRT), endobronchial brachytherapy, chemotherapy, radiotherapy, bronchoscopic debulking, surgical resection, photodynamic therapy, and Neodymium-doped yttrium aluminum garnet (Nd:YAG) are discussed as treatment options. For superior vena cava obstruction, external beam radiation EBRT, RT dose fractionation, SVC stent insertion, steroids, and palliative intent chemotherapy are discussed.

Sentinel Node Biopsy in Primary Cutaneous Melanoma

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline reviews the use of sentinel node biopsy (SLNB) as a diagnostic tool for adult patients with malignant melanoma. Topics of discussion include indications and contraindications of SLNB, pathological examination of the sentinel nodes, and indications for therapeutic node dissection and recommended extent of dissection. The use of ultrasound-guided fine-needle aspiration is also discussed. Outcomes of interest include test sensitivity, specificity, and positive and negative predictive value, as well as rate of nodal recurrence and survival.

Esophageal Cancer

Year: 2016
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with esophageal cancer, including both squamous cell and adenocarcinoma. The guideline provides recommendations on diagnostic work-up, staging, treatment options for potentially curable cancer stratified by stage, and management options for incurable cancer. Esophagectomy, endoscopic therapy, primary chemoradiotherapy, radiotherapy, pre-operative chemoradiotherapy followed by esophagectomy and pre-operative chemotherapy are discussed, as well as supportive care. Outcomes of interest include survival (overall, progression-free, 5-year), morbidity, toxicity, and rate of sudden death.

Influenza Immunization For Adult And Pediatric Patients Undergoing Cancer Treatment

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult and pediatric patients with solid tumours or hematologic cancers. The guideline provides recommendations on influenza immunization including immunization interval and dosage, type of vaccine (activated versus inactive), and timing of administration in relation to the cancer treatment cycle. Special topics of interest include immunization of patients undergoing blood and marrow transplant (BMT, autologous and allogeneic), as well as immunization of family members and hospital or clinic staff who are in contact with cancer patients.

Tobacco Screening And Treatment For Adult Cancer Patients

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults (aged 18 and older) at any phase of the cancer care continuum regardless of cancer type, stage (including metastatic) or treatment plan, with some components of the guideline also applicable to the patient's family and/or caregivers. The guideline provides recommendations on implementation of the brief tobacco intervention, using the evidence-based 5 A’s model (ASK, ADVISE, ASSESS, ASSIST, ARRANGE) which includes screening, education and assessment, treatment plan, and referral, monitoring, and follow-up. Clinical considerations and contraindications of treatment options for cancer patients are discussed including nicotine replace therapy (NRT), bupropion, varenicline, and e-cigarettes. The impact of tobacco use on cancer treatment is also reviewed with a specific focus on erlotinib and irinotecan.

Multiple Myeloma

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is an update to the 2013 clinical practice guideline for the management of multiple myeloma in adult patients. The guideline examines diagnosis and treatment for multiple myeloma, monoclonal gammopathy, smoldering myeloma, and amyloidosis, including prognostic criteria. Outcomes of interest include improved survival outcomes through triple drug based induction regimens and improved dose reduction options for elderly patients.

Lymphoma

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline addressing lymphoma in the adult population. The guideline focuses on the following areas: Diagnosis and Pathologic Classification, Staging, Treatment of Non-Hodgkin Lymphomas, Hodgkin Lymphoma, HDCT and hematopoietic stem cell transplantation for lymphoma, supportive care in the treatment of lymphoma, and follow-up care in the treatment of lymphoma. Additionally, it seeks to provide recommendations to the following questions: what are the diagnostic criteria for the most common lymphomas; what are the staging and re-staging procedures for Hodgkin and non-Hodgkin lymphomas; what are the recommended treatment and management options for Hodgkin and non-Hodgkin lymphomas; and what are the recommended follow-up procedures for patients with malignant Hodgkin and non-Hodgkin lymphoma.

Management of Chronic Myeloid Leukemia

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the management of chronic myeloid leukemia (CML) in adult patients over 18 years of age. The 2015 update incorporates new evidence from research involving tyrosine kinase inhibitors for the treatment of CML. Guideline recommendations stem from the following three questions: what diagnostic and baseline investigations are recommended for adult patients with suspected or confirmed CML; what are the recommended treatment options for CML; and what are the criteria for monitoring response to treatment?

Acute Promyelocytic Leukemia

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the diagnosis and management of acute promyelocytic leukemia (APL) in adult patients over the age of 18 years. As a unique subtype of acute myeloid leukemia (AML), APL has distinct clinical features and management when compared to other forms of AML and therefore, these guidelines serve as a supplement to the AML guidelines. The guideline recommendations are drawn from the following questions: what are the diagnostic criteria for APL; what is the recommended management for adult patients in Alberta with APL; and what is the recommended follow-up for adult patients in Alberta with APL.

The Organization and Delivery of Healthcare Services for Head and Neck Cancer Patients

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the organization and delivery of health-care services for head and neck cancer patients in Alberta. The recommendations centre around responses to a number of guideline questions including: what does the health-care team treating head and neck cancer patients look like; what are the minimum qualifications required by core team members; what are the minimum cancer centre and team member volumes that optimize clinical outcomes; and what are the unique infrastructure requirements of team members.

Oropharyngeal Cancer Treatment

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the diagnosis, treatment, and follow-up of oropharyngeal cancer. The guideline examines baseline assessment and imaging, and treatment options based on patient staging. Important aspects include patient treatment preference and prioritization of treatment options based on risk features.

Metastatic Colorectal Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult patients with metastatic colorectal cancer. The guideline examines treatment, primarily though palliative chemotherapy regimens. Outcomes of interest include delayed disease progression through monoclonal antibodies and improved treatment planning through the identification of RAS testing.

Influenza Immunization For Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline provides recommendations on influenza vaccinations for children and adults with solid tumours or hematologic malignancies. Recommendations are provided for vaccine type (live versus inactivated) and administration in relation to the therapy cycle, and are stratified by patient age (adult versus pediatric). Topics of discussion include the effects of age, duration, and type of systemic therapy in regards to response of patients to the influenza vaccine, as well as contraindications and precautions for immunization.

Systemic Therapy for Unresectable Stage III or Metastatic Cutaneous Melanoma

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over the age of 18 years with unresectable stage III and stage IV cutaneous melanoma, without involvement of the central nervous system (CNS). The guideline reviews the use of BRAF biomarker testing, and provides recommendations for first- and second-line systemic therapy options. BRAF Inhibitors, MEK inhibitors, immune checkpoint Inhibitors, other biological agents (e.g. imatinib and bevacizumab), and chemotherapy agents are reviewed.

Merkel Cell Carcinoma

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over the age of 18 years with Merkel cell carcinoma of the skin. The guideline provides recommendations on staging and work-up, treatment options including surgery, radiation, and chemotherapy, and follow-up care. The guideline also provides recommendations on management of recurrences, and reviews sentinel lymph node biopsy protocol.

Follow-Up Care For Early-Stage Breast Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients who have completed active medical or radiation oncology treatment for early-stage breast cancer and who have been discharged by the cancer care centre for care by the referring physician. The guideline provides recommendations on responsibilities regarding follow-up care, follow-up investigations and surveillance, and signs and symptoms indicative of a breast cancer recurrence. Potential complications from cancer treatment and common survivorship concerns and challenges are also reviewed.

Endometrial Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for women with endometrial cancer, including uterine carcinosarcoma. The guideline provides recommendations on lynch syndrome screening, surgery, adjuvant treatment for completely surgically staged endometrioid carcinoma, and adjuvant treatment for surgically staged high risk histotypes including endometrial serous, clear cell, dedifferentiated/undifferentiated carcinomas and carcinosarcomas. The guideline also reviews therapy for relapsed patients, and follow-up and surveillance of women without evidence of disease after primary potentially curative treatment for any stage of endometrial cancer.

Cancer Of The Uterine Cervix

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of adult patients with cancer of the uterine cervix, including squamous, adenocarcinomas, and adenosquamous carcinomas. The guideline examines treatment, primarily through surgery and radiotherapy, staging, and follow-up. Outcomes of interest include improved survival benefits through chemoradiotherapy and improved outcomes thought the addition of ifosamide to recommended chemotherapies.

Panitumumab And Cetuximab Toxicity Management Guidelines

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with advanced colorectal cancer. The guideline reviews the safe administration of Panitumumab or Cetuximab (anti-EGFR therapy). Monitoring and treatment of adverse treatment effects are reviewed, including cutaneous toxicities, diarrhea, hypomagnesemia, fatigue, asthenia, lethargy, or malaise, hypersensitivity reactions, and interstitial lung disease.

Adjuvant Radiotherapy for Ductal Carcinoma In Situ

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This guideline provides recommendations on adjuvant radiotherapy for adult patients with ductal carcinoma in situ (DCIS) who have undergone breast conserving surgery (BCS) or mastectomy. The handling of close radial margin of excision after BCS is considered. Dose/fractionation schedule and acute toxicity are discussed, as are the side effects of radiotherapy.

Systemic Therapy for Well and Moderately Differentiated Unresectable Pancreatic Neuroendocrine Tumours

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients diagnosed with well or moderately differentiated (grade 1 or 2) pancreatic neuroendocrine tumours (PNETs). The guideline reviews the use of targeted therapies for PNETs including sunitinib malate, everolimus, and combination treatment with capecitabine/temozolomide. Recommendations are provided on use, dose, and schedule. Outcomes of interest include progression free survival (versus placebo) and toxicity.

Somatostatin Analogues for the Management of Neuroendocrine Tumours

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline looks at the use of somatostatin analogues in management of neuroendocrine tumours. Topics reviewed include the use of somatostatin analogues for management of secretory syndromes as a result of tumours, the effectiveness in use for delaying tumour progression, and effectiveness in use for management of carcinoid heart disease. Otreotide is looked at for effectiveness in management of symptoms secondary to elevated calcitonin in medullary thyroid carcinoma. Outcomes of interest include treatment response, survival, and adverse events.

Adenocarcinoma of the Pancreas

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with adenocarcinoma of the pancreas. The guideline discusses diagnostic workup, treatment options for potentially curable adenocarcinoma of the pancreas, and management of unresectable adenocarcinoma of the pancreas including locally advanced and metastatic disease. Surgical and first and second line systemic treatment options are discussed. Toxicity of systemic therapy regimes is also reviewed.

Adjuvant Radiation Therapy For Invasive Breast Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with invasive breast cancer who have had breast conserving surgery (BCS) or a mastectomy. The guideline reviews radiotherapy treatment according to lymph node status (positive or negative). Additionally, recommendations are provided for radiotherapy treatment with neoadjuvant chemotherapy, and the guideline discusses the risk of cardiac dose for patients with left-sided breast cancer and how this risk might be minimized.

Prostate Cancer

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline provides recommendations on management of prostate cancer, including diagnosis and screening, management stratified by risk, and follow up care. Active surveillance, surgery (radical prostatectomy), external beam radiotherapy (EBRT), low dose rate (LDR) brachytherapy, cryosurgery, High Intensity Focused Ultrasound (HIFU), Androgen Deprivation Therapy (ADT), and systemic therapies are discussed as treatment options. Bone health is also reviewed. Outcomes of interest include survival and recurrence.

Acute Myeloid Leukemia

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients over the age of 18 years with acute myeloid leukemia. The guideline reviews diagnosis, classification, ancillary tests, response criteria, prognosis/risk stratification, risk groups as per cytogenetic or molecular status, and management options. Treatments reviewed include chemotherapy, hematopoietic stem cell transplantation, and palliation. Follow up care is also discussed.

Person-Centred Care Guideline

Year: 2015
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This guideline addresses person-centred care for adults 18 years and older in Ontario using oncology services. The guideline discusses the importance of treating patients as individuals and provides recommendations on putting patients first and ensuring that essential requirements of care such as respect for the patient, patient concerns, nutrition, pain management and personal needs, patient independence, and consent and capacity, are met. Additionally, the guideline provides recommendations on tailoring healthcare service for each patient and enabling patients to actively participate in their care.

Prophylaxis and Treatment of Venous Thromboembolism in Patients Undergoing Treatment for Solid Tumours

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for ambulatory and inpatients undergoing treatment for solid tumours, at risk for venous thromboembolism. The guideline examines appropriate surveillance and follow up, and treatment through anticoagulants. Outcomes of interest include improved recommendations for the elderly and clarified preoperative medication timelines.

Oncologic Emergencies: A Guide for Family Physicians

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the treatment of oncological emergencies related to cancer or anticancer therapy for family physicians. The guideline examines complications associated with cancer and cancer therapy, including diagnosis and treatment. Outcomes of interest include improved patient safety and reduced unnecessary treatment.

Follow-Up Surveillance of Soft Tissue Sarcoma

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients who have undergone treatment for soft tissue sarcomas. The guideline examines appropriate surveillance and follow up methods, including regular imaging and physical examination. Outcomes of interest include preference for x-rays over MRI or CT, and increased postoperative imaging.

Management of Malignant Pleural Effusion

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with suspected or diagnosed malignant pleural effusions. The guideline examines diagnosis and treatment for symptomatic and asymptomatic patients, including therapeutic thoracentesis. Outcomes of interest include improved relief of dyspnea and reduced hospital stay time.

Oral Cavity Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with suspected or diagnosed oral cavity cancer. The guideline examines diagnosis, treatment, and potential reconstruction depending on cancer stage and site-specificity. Outcomes of interest include improved functional outcomes through reconstruction and improved adjuvant therapy for patients with increased risk factors.

Metastatic Colorectal Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with metastatic colorectal cancer. The guideline reviews surveillance and treatment options including surgery, radiotherapy, palliative chemotherapy and biological therapy. Outcomes of interest include survival (overall, progression-free), and toxicity.

Hepatocellular Carcinoma

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with hepatocellular carcinoma. The guideline provides recommendations on diagnostic assessment, staging, and management. Treatment options including resection, liver transplantation, radiofrequency ablation (RFA), percutaneous ethanol injection (PEI), transarterial chemo-embolization (TACE), transarterial radioembolization (TARE), sorafenib, and stereotactic body radiotherapy (SBRT) are reviewed.

Stages II and III Colorectal Cancer Surveillance

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over the age of 18 years with stage II or III colorectal cancer. The guideline discusses follow-up care and provides recommendations regarding the timing and appropriateness of surveillance tests/procedures including CEA testing, colonoscopy, PET scans and CT scans. The guideline also discusses how physicians can educate patients about adopting healthy lifestyle behaviours to improve survival outcomes.

Adenocarcinoma of the Pancreas

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with pancreatic cancer. The guideline reviews diagnostic work-up, staging, and treatment options for both potentially curable and unresectable pancreatic cancer. Comparisons are made between FOLFIRINOX and gemcitabine chemotherapy regimes. Outcomes of interest include survival, adverse events, and response rate.

Uveal Melanoma

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with malignant uveal melanoma. The guideline reviews diagnosis and work-up, primary management, adjuvant therapy, management of patients with metastatic disease, and management of high risk patients. Follow-up care is also discussed. Outcomes of interest include efficacy of treatments and imaging modalities.

Seizure Management in Patients with Primary and Metastatic Brain Tumours

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over the age of 18 years with primary or metastatic brain tumours. The guideline provides recommendations on the management of seizures caused by brain tumours. Treatment options discussed include antiepileptic drugs, surgery, and radiation therapy. The guideline also reviews driving guidelines for those patients experiencing seizures, particularly in the context of the province of Alberta and the associated Alberta Transportation rules and regulations.

Medulloblastoma

Year: 2014
AGREE II score: Available
Developer organization: Alberta Health Services
A clinical practice guideline for the treatment of newly diagnosed and recurrent or relapsed medulloblastoma in adult patients. The guideline examines MRI workup, surgery with maximal safe resection, and management of localized and non-localized recurrence. Outcomes of interest include improved long-term survival rates with maximal excision and improved local control with postoperative radiotherapy.

Management of Primary Germ Cell Tumours of the Central Nervous System

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over the age of 18 years with primary germ cell tumours (GCTs) of the central nervous system. The guideline discusses staging and diagnosis, treatment, and follow-up care. Recommendations for treatment options are provided for germinoma and nongerminomatous GCT, and are stratified by whether disease is localized or metastatic. Additional recommendations are made for recurrent treatment, again stratified by histology.

Management of Recurrent High-Grade Gliomas

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over the age of 18 years with recurrent high-grade gliomas, including grade III anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas and grade IV glioblastomas. The guideline discusses diagnostic assessment for recurrence, and treatment options including systemic therapy, surgery, and re-irradiation. Factors of consideration when determining treatment course are also discussed.

Neo-Adjuvant (Pre-Operative) Therapy for Breast Cancer – General Considerations

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients 18 years or older with non-metastatic breast cancer. The guideline discusses neo-adjuvant therapy for breast cancer, including eligibility, advantages and dis-advantages, available therapies. Optimal treatment monitoring, surgical considerations, and the role of radiotherapy are also discussed. Outcomes of interest include prognostic factors, response rate, accuracy of diagnostic procedures, survival (disease-free, overall), and relapse rate.

Adjuvant Systemic Therapy for Early Stage (Lymph Node Negative and Lymph Node Positive) Breast Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a guideline for adjuvant systematic therapy for early stage (lymph node negative and lymph node positive) breast cancer. The guideline discusses risk categories for lymph node negative breast cancer, provides treatment recommendations for lymph node negative breast cancer, and explores chemotherapy options for lymph node negative breast cancer. Other areas of interest include: treatment recommendations for lymph node positive breast cancer, chemotherapy options for lymph node positive breast cancer, and adjuvant hormonal therapy for hormone receptor positive disease only.

Adjuvant Radiation Therapy for Ductal Carcinoma In Situ

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline practice guideline for adult patients with ductal carcinoma in situ (DCIS) who have had breast-conserving surgery or a mastectomy. The guideline considers what the optimal radiotherapy treatment after surgery would be for patients with DCIS, as well as how a close radial margin of excision should be handled following breast conserving surgery. Additional areas of interest include: toxicity and side effects of radiotherapy.

Adjuvant Radiation Therapy for Invasive Breast Cancer

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with invasive breast cancer who have had breast-conserving surgery or a mastectomy. The guideline examines what is the optimal radiotherapy treatment after surgery for patients with T1, T2, T3, T4 invasive breast cancer according to lymph node status. Other outcomes of interest include: the manner in which a positive margin should be handled for patients with breast conserving surgery, as well as what the optimal radiotherapy treatment after surgery should be for patients with invasive breast cancer who have had neoadjuvant chemotherapy.

Adjuvant Interferon for Malignant Melanoma

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults with malignant melanoma. The guideline considers whether adjuvant interferon alpha should be offered to patients who have been rendered disease-free following the resection of cutaneous melanomas and who are at high risk for subsequent recurrence. Issues discussed include: steps of treatment, potential side effects, special considerations (such as toxicity, and patient education), and follow-up.

Palliative Radiotherapy: Brain Metastases

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients, with single or multiple brain metastases, arising from cancer of any histology, excluding germ cell tumours and hematologic malignancies. The guideline examines strategies for the management and treatment of adults with: a newly diagnosed solitary brain metastasis, newly diagnosed multiple brain metastases, as well as progressive or recurrent brain metastases. Management and treatment options explored vary by whether the metastatic disease is solitary, multiple, recurrent or progressive but include: neurosurgery, whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), as well as supportive care.

Management of Patients With Early Esophageal Cancer, Dysplastic and Non-Dysplastic Barrett’s Esophagus

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for the management of patients with early esophageal cancer, dysplastic and non-dysplastic Barrett's esophagus. This guideline examines treatment options and considers in what clinical situations endoscopic therapy is the most appropriate treatment. Treatment options explored and discussed include: endoscopic mucosal resection, radiofrequency ablation, photodynamic therapy, argon plasma coagulation, and multipolar electrocoagulation.

Guideline for Primary Antifungal Prophylaxis for Pediatric Patients with Cancer or Hematopoietic Stem Cell Transplant Recipients

Year: 2014
AGREE II score: Available
Developer organization: C17 Children's Cancer & Blood Disorders
A clinical practice guideline for pediatric patients with hematopoietic cancer or receiving stem cell transplants. The guideline examines antifungal prophylaxis to prevent invasive fungal infections, primarily through fluconazole. Outcomes of interest include lower rates of fungal related mortality and improved optimal pediatric dosing.

Sentinel Node Biopsy in Primary Cutaneous Melanoma

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline reviews the use of sentinel node biopsy (SLNB) as a diagnostic tool for adult patients with malignant melanoma. The guideline reviews indications and contraindications of SLNB, pathological examination of the sentinel nodes, and indications for therapeutic node dissection and recommended extent of dissection. The use of ultrasound-guided fine-needle aspiration is also discussed. Outcomes of interest include test sensitivity, specificity, and positive and negative predictive value, as well as rate of nodal recurrence and survival.

Management of Febrile Neutropenia in Adult Cancer Patients

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline reviews the risk factors, assessment, treatment and overall management of febrile neutropenia in adult cancer patients. Combination therapy, monotherapy, and empiric vancomycin are discussed as treatment options and recommendations are provided for dosage and schedule. Outcomes of interest include success rate of antibiotic treatment, failure rate, survival, and mortality.

Chronic Lymphocytic Leukemia

Year: 2014
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients over 18 years of age with possible chronic lymphocytic leukemia. The guideline reviews the management of chronic lymphocytic leukemia, including diagnosis and prognosis, first-line and second-line treatment options, and follow-up and supportive care. Outcomes of interest include survival (overall and progression-free), toxicity, overall response, and quality of life.

The Organization and Delivery of Healthcare Services for Head and Neck Cancer Patients

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical and organizational guideline for the management and delivery of services to head and neck cancer patients. The guideline examines delivery of care, healthcare qualifications, and infrastructure factors related to treatment and follow up. Important aspect include multidisciplinary team requirements including certifications and minimum patient volumes, and appropriate wait times for assessments and therapies.

Gastric Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over the age of 18 with gastric cancer. The guideline discusses diagnostic work-up, staging, and treatment recommendations. Outcomes of interest include survival (overall and five-year progression-free), and side effects of therapy.

Esophageal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with esophageal cancer, including both squamous cell and adenocarcinoma. The guideline provides recommendations on diagnostic work-up, staging, treatment options for potentially curable cancer, and management options for incurable cancer. Outcomes of interest include survival (overall, progression-free, 5-year), morbidity, toxicity, and rate of sudden death.

Early Stage Rectal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with early stage rectal cancer. The guideline reviews diagnostic work-up, staging, and treatment options including surgical resection and chemotherapy.

Early Stage Colon Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over 18 years of age with early stage colon cancer. The guideline provides recommendations on diagnostic work-up, staging, and treatment including a review of recommended chemotherapy regimes.

Anal Canal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over 18 years of age with squamous cell carcinomas that arise in the anal canal. The guideline discusses diagnostic work-up, staging, and the goals of therapy and recommendations for both potentially curable, locally recurrent, and metastatic cancer of the anal canal. Follow-up care is also reviewed.

Cholangiocarcinoma and Gallbladder Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with biliary tract cancer. The guideline examines management, with specific focus on surgical resection for potentially resectable disease and palliative radiotherapy for unresectable disease. Outcomes of interest include improved recommendations for establishing resectability and reductions in endoscopic retrograde cholangiopancreatogram.

Testicular Germ Cell Tumours

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with testicular germ cell tumours. The guideline reviews diagnostic assessment, staging, management, and follow-up care for both seminoma and nonseminomas. Outcomes of interest include survival (overall, disease free), complete response rate, recurrence rates, and toxicity.

Prevention of Skin Cancer

Year: 2013
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for individuals at high risk of sustaining UV damage, leading to the development of skin cancer later in life. The guideline reviews risk assessment and sun protection strategies, and provides recommendations on counselling and interventions for limiting UV exposure in high-risk individuals, such as legislation on indoor tanning, policies on use of sun protection in high risk settings, social marketing and mass media campaigns, and education on sun protection. Outcomes of interest include effectiveness of interventions (measured by sunscreen use, use of hats, etc.), ultraviolet (UV) rates, and skin cancer rates.

Preoperative and Pretreatment Investigations for Malignant Melanoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients 18 years of age or older with malignant melanoma. The guideline reviews clinical presentation and preliminary work-up for malignant melanoma as well as additional work-up depending on stage. Outcomes of interest include cost-effectiveness, and specificity and sensitivity of diagnostic procedures.

Octreotide for the Management of Neuroendocrine Tumours

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of neuroendocrine tumours of the gastrointestinal tract, pancreas, lungs, thyroid, parathyroid, adrenal glands, and pituitary gland, and of unknown origin. The guideline examines symptom management and dosing regimens for treatment with octreotide. Outcomes of interest include slowed tumour progression and improved prophylactic use.

Nonmuscle Invasive Bladder Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of patients with nonmuscle invasive bladder cancer, identified as stages Tis, Ta, and T1. The guideline examines adjuvant therapy, recurrence prevention, and appropriate follow-up, with specific focus on maintenance therapy and treatment failure. Outcomes of interest include improved recommendations for bacillus calmette-guerin therapy and its use in improved maintenance therapy.

Nasopharyngeal Cancer Treatment

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of patients with, or suspected of having, nasopharyngeal cancer. The guideline examines baseline investigation procedures, treatment options with a specific focus on radiotherapy, and follow-up. Outcomes of interest include improved treatment strategies for advanced stage patients, and improved concurrent chemotherapy options.

Multiple Myeloma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of multiple myeloma in adult patients. The guideline examines diagnosis and treatment for multiple myeloma, monoclonal gammopathy, smoldering myeloma, and amyloidosis, including prognostic criteria. Outcomes of interest include improved survival outcomes through triple drug based induction regimens and improved dose reduction options for elderly patients.

Mitotane for the Management of Adrenocortical Carcinoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of patients diagnosed with adrenocortical carcinoma. The guideline examines the use of adjuvant mitotane therapy in resectable and unresectable carcinomas, and options for combination therapy. Outcomes of interest include lower rate of recurrence post-surgery and prolonged survival in children.

Management of Resectable Stage IV Primary Cutaneous Melanoma Without Nodal Disease

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with resectable stage IV primary cutaneous melanoma without nodal disease. The guideline examines treatment options, including chemoimmunotherapy and surgical resection of distant sites. Outcomes of interest include improved survival times and improved patient selection for chemoimmunotherapy.

Follow-Up Care for Early-Stage Breast Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients who have completed treatment for early-stage breast cancer. The guideline examines surveillance follow-up for potential recurrence, with specific focus on potential complications from previous treatment. Outcomes of interest include improved management of endocrine therapy complications and improved lymphadema management.

Biopsy of a Suspicious Pigmented Lesion

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients presenting with a mole or lesion that is suspicious for melanoma. The guideline examines biopsy techniques and diagnostic elements. Outcomes of interest include reducing misdiagnosis and testing inaccuracy.

Management of In-Transit Disease of the Limbs

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with melanoma with in-transit disease of the limbs. The guideline examines treatment options, including surgical resection and systemic therapy, depended on staging. Outcomes of interest include improved recommendations for isolated limb infusion, with no consensus on preferred systemic therapy.

The Use Of Dexamethasone In Patients With High Grade Gliomas

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the use of dexamethasone in corticosteroid therapy for patients with high-grade gliomas. The guideline examines optimal dose ranges and adverse events associated with dexamethasone, and its overall management including tapering. Outcomes of interest include improved monitoring of and prevention of associated illnesses and improved follow-up for adrenal symptoms.

Upper Tract Urothelial Tumours

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult patients with upper tract urothelial carcinoma. The guideline examines staging, treatment, and follow-up, focusing on laboratory work-ups and primary therapy. Outcomes of interest include reduction of tumour recurrence through open bladder cuff excision and higher response rates with neoadjuvant chemotherapy.

Extragonadal Germ Cell Tumours

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult patients with primary mediastinal or retroperitoneal germ cell tumours. The guideline examines diagnosis and treatment, via chemotherapy and surgery, and suggested follow-up via prognosis. Outcomes of interest include improved reduction of disease recurrence and reduced hepatobiliary toxicity.

Systemic Therapy for Unresectable Stage III or Metastatic Cutaneous Melanoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult patients with metastatic or unresectable stage III melanoma with possible metastatic sites in distant skin, lymph nodes, liver, lungs, bone, and the brain. The guideline examines appropriate systemic therapies and dosing regimens for first- and second-line treatments. Outcomes of interest include improved survival outcomes and increased efficacy of combination therapies.

Uterine Sarcoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for adult female patients with uterine sarcomas, including leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma. The guideline examines optimal surgical staging, adjuvant therapy, and palliative therapy. Outcomes of interest include improved progression-free survival rates and improved survival with the combination of gemcitabine and docetaxel.

Lymphoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with lymphoma. The guideline examines diagnostic assessment and staging procedures as well as treatment and management options. Follow-up and supportive care are also reviewed. Outcomes of interest include response rate (complete and overall), survival (progression-free and overall), time to disease progression, remission duration, freedom from treatment failure, impact of treatment on fertility, and toxicity from treatment.

Ovarian Germ Cell Tumours

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline reviews management/treatment of and follow-up care for women with ovarian germ cell tumours. Topics of interest include the efficacy of four cycles of etoposide and cisplatin as compared to the standard therapy with three cycles of bleomycin, etoposide, and cisplatin. Supportive care for myelosuppression is also discussed. Outcomes of interest include survival, mortality, relapse, time to progression, treatment response, and treatment complications and side effects.

Optimal Excision Margins for Primary Cutaneous Melanoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with malignant melanoma. The guideline discusses minimal optimal excision margins for melanoma, in general, with special consideration to melanomas of the face and distal extremities. Interventions considered include excisional biopsy, radiotherapy, topical imiquimod, Mohs micrographic surgery, sentinel node biopsy (SNB) and wide local excision. Outcomes of interest include survival, recurrence rate, and rate of local control.

Optimal Use of Taxanes in Metastatic Breast Cancer (MBC)

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adults over the age of 18 years with metastatic breast cancer who are anthracycline naïve or pre-treated/resistant. The guideline examines the use of taxane treatment for women depending on whether they have previously been treated with anthracycline, and whether or not the tumour shows HER2 overexpression. The guideline also reviews the use of taxanes to treat women who are anthracycline naïve or pretreated/resistant and paclitaxel or docetaxel intolerant. Outcomes of interest include risk of disease progression, toxicity rates, adverse effects of treatment, response rates, mortality, and quality of life.

Squamous Cell Carcinoma of the Vulva

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with squamous cell carcinoma of the vulva. The guideline reviews pre-operative investigations, primary treatment, adjuvant treatment, and follow-up and surveillance, with general and stage-specific recommendations provided. Outcomes of interest include cancer-related death rate, survival (overall and disease-free), progression-free interval, local control, and recurrence rate.

Breast Reconstruction Following Prophylactic or Therapeutic Mastectomy for Breast Cancer

Year: 2013
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult women who are candidates for mastectomy, either for the treatment of breast cancer or for the prophylaxis of breast cancer in patients at high genetic risk. The guideline reviews eligibility for post-mastectomy breast reconstruction and provides recommendations on type and timing of reconstruction after review of the benefits and risks. Post-breast reconstruction surveillance is also reviewed. Outcomes of interest include post-reconstruction complications (short and long term), quality of life, local recurrence, failure rate, cost effectiveness, and aesthetic outcomes.

Muscle Invasive and Locally Advanced/Metastatic Bladder Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with muscle invasive bladder cancer (i.e., stages T2a/b, T3a/b, T4a and N0-X, M0). The guideline reviews evaluation and staging, treatment, and follow-up care according to stage. Outcomes of interest include survival, recurrence rate, bladder preservation rate, rate of metastasis, and presence of residual disease.

Referral and Follow-up Surveillance of Cutaneous Melanoma

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients 18 years of age or older with malignant melanoma. Referral of patients to the cancer treatment centre is reviewed and follow-up and surveillance are discussed, with stage-specific recommendations provided. Outcomes of interest include quality of life, overall survival, regional control, time and expense of surveillance, and test sensitivity and false positive rates.

Non-Small Cell Lung Cancer Stage IV

Year: 2013
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with Stage IV non-small cell lung cancer. Treatment options are discussed including the role of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in first-line treatment, options for second-line therapy, and the role of palliative radiotherapy. Outcomes of interest include tumour response rate, survival (1-year, overall), time to progression, quality of life, and treatment-related adverse events.

Cancer of the Uterine Cervix

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with cancer of the uterine cervix, including squamous, adenocarcinomas, and adenosquamous carcinomas. The guideline reviews evaluation and staging, treatment, and follow-up procedures. Management of recurrent disease is also discussed. Outcomes of interest include survival (overall, disease-free, and progression-free), overall response rate, and toxicity.

Proton Beam Radiation Therapy

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This clinical practice guideline reviews the use of proton beam radiation therapy to treat cancers in pediatric, adolescent, and adult patients. The guideline examines the benefits of proton beam radiation therapy for different cancer types, and discusses the referral and funding process for out-of-country treatment. Outcomes of interest include local control, survival (progression-free and overall), acute and late toxicities, and recurrence rates.

Epithelial Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients over 18 years of age with epithelial ovarian cancer. The guideline provides treatment recommendations with consideration to stage, grade, and tumour type. Treatment options are discussed including various chemotherapy regimes, surgery, and radiotherapy. Treatment of recurrent disease and post-treatment follow up and surveillance are also reviewed. Outcomes of interest include overall and progression-free survival, and clinical remission.

Endometrial Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients with endometrial cancer including uterine carcinosarcoma. The guideline examines treatment options including surgery, radiotherapy, chemotherapy and hormone therapy. Therapy for relapse and follow-up and surveillance care are also reviewed. Outcomes of interest include recurrence, 5-year progression-free survival, 5-year overall survival, and toxicity.

Prostate Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for men with prostate cancer or suspected prostate cancer. The guideline provides an overview of early diagnostic and screening procedures, management and treatment options, and follow-up care for low-risk, intermediate-risk, and advanced disease. The guideline also reviews bone health and the use of bisphosphonates as treatment for castrate resistant disease. Outcomes of interest include mortality, quality of life, morbidity, treatment complications, and toxicity.

Influenza Immunization for Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2013
AGREE II score: Available
Developer organization: Alberta Health Services
A clinical practice guideline for influenza immunization in patients undergoing cancer treatment or palliative cancer care. The guideline examines the use of live vaccines and timelines for immunization based on ongoing treatment. Outcomes of interest include higher immunization response and reduced disease transmission risk.

Thymic Neoplasms

Year: 2012
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with thymic neoplasms. The guideline examines staging based treatment and follow up, focusing on surgical resection and postoperative radiotherapy. Outcomes of interest include reduced relapse and improved multimodal treatment regimens.

Renal Cell Carcinoma

Year: 2012
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for the management of patients with renal cell carcinoma. The guideline examines diagnostic assessment and appropriate first and second line therapies, including surgical and minimally invasive therapies. Outcomes of interest include increased assessment for treatment tolerance, and improved median survival.

Adjuvant Radiation for Malignant Melanoma

Year: 2012
AGREE II score: Unavailable
Developer organization: Alberta Health Services
This is a clinical practice guideline for patients over 18 years of age with malignant melanoma. The guideline discusses the use of adjuvant radiation therapy with consideration to cancer stage and whether the cancer being treated is recurrent. Contraindications are also reviewed. Outcomes of interest include survival and control rates.

Prevention and Treatment of Rash in Patients Treated with EGFR Inhibitor Therapies

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for adult patients with advanced non-small cell lung cancer, colorectal cancer, head/neck cancer, or breast cancer, that is treated with the epidermal growth factor receptor (EGFR) inhibitors cetuximab, erlotinib, gefitinib, panitumumab, or lapatinib, either alone or in combination with other treatments. The guideline examines the prevention and management of a papulopustular rash that commonly develops as a side effect of EGFR inhibitor therapy. Topics of discussion include prevention and prophylactic treatment of rash, clinical management, and supportive care. Outcomes of interest include rash severity, rate of recurrence, and response to treatment.

Pneumococcal Vaccination in Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline on pneumococcal immunization among adult and pediatric cancer patients. The guideline outlines vaccination types, provides recommendations on the timing of immunization with regards to cancer treatment, and reviews contraindications. Outcomes of interest include pneumococcal immunization response rates and vaccine-related adverse events.

Influenza Immunization for Adult and Pediatric Patients Undergoing Cancer Treatment

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This clinical practice guideline provides recommendations for influenza immunization among adult and pediatric cancer patients. Guideline topics include the effect of cancer treatment on immunization response, immunization contraindications and precautions, and timing of immunization with regards to chemotherapy, radiotherapy, and blood and marrow transplant. Immunization of family and hospital staff who come in contact with patients is also discussed. Outcomes of interest include influenza immunization response rates and vaccine-related adverse events.

Small Cell Lung Cancer: Limited Stage

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for the treatment of limited stage small cell lung cancer in adult patients. The guideline reviews chemoradiotherapy, prophylactic cranial irradiation, second line chemotherapy, and surgery as treatment options. Outcomes of interest include tumour response, survival rates, and adverse effects.

Small Cell Lung Cancer: Extensive Stage

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for the treatment of extensive stage small cell lung cancer in adult patients. The guideline reviews treatment options including platinum based combination chemotherapy, prophylactic cranial irradiation, thoracic irradiation, and second line chemotherapy. Outcomes of interest include response rate and adverse effects.

Lymphoma

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline on the diagnosis, staging, treatment, supportive interventions and follow-up care for adult patients with lymphoma. Staging techniques include immunohistochemical and fluorescence in situ hybridization (FISH) testing. Treatment and management options are discussed for Hodgkin and non-Hodgkin lymphomas, with recommendations based on cancer type and stage. Outcomes of interest include response rates, disease progression, survival, remission, and adverse effects.

Management of Chronic Myeloid Leukemia

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline on the management of chronic myeloid leukemia in patients over 18 years of age. The guideline provides recommendations on staging and prognosis, diagnosis and baseline investigations, treatment options, and treatment response assessment. First and second generation TKI's, induction chemotherapy, allogeneic stem cell transplant, and interferon-a are all discussed as treatment options. Outcomes of interest include treatment efficacy, survival rate, disease progression, and adverse events.

The Organization and Delivery of Healthcare Services for Head and Neck Cancer Patients

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a professional guideline that provides recommendations on the organization and delivery of health-care services for head and neck cancer patients in Alberta. The guideline outlines the professional health-care team involved in the treatment of head and neck cancer patients, including their roles and minimum required qualifications. It also provides guidance on minimum infrastructure requirements, optimal cancer centre and team member volumes, and wait times to care from referral to initiation of curative treatment.

Gestational Trophoblastic Neoplasia

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for women with gestational trophoblastic neoplasia, including invasive mole, choriocarcinoma, and placental site trophoblastic tumour. The guideline provides recommendations on diagnostic assessment, staging, prognostic scoring, treatment, and follow-up procedures. Outcomes of interest include diagnostic accuracy, complete response rate, survival rate, and risk of subsequent abnormal pregnancy.

Pituitary Adenomas

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for the treatment of hormonally active (functioning) and non-functioning pituitary adenomas in adult patients. Surgery, postoperative radiation, and drug therapy are all reviewed as treatment options. Outcomes of interest include symptom management, tumour response, and remission rates.

Meningiomas

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for the treatment of low-grade (WHO grade I), atypical (WHO grade II), and anaplastic (WHO grade III) meningiomas in adult patients. Active surveillance, surgery, radiotherapy, and systemic therapy are all examined as treatment options. Outcomes of interest include survival and recurrence.

Glioblastoma

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline on the management of adult patients with glioblastoma. The guideline provides treatment recommendations and discusses the prognostic value of MGMT promoter methylation. Surgery, external beam radiation, and chemotherapy are discussed as treatment options. Outcomes of interest include survival rates and quality of life.

Ependymomas

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
A clinical practice guideline for patients over the age of 18 with WHO grades II or III anaplastic ependymomas. The guideline provides recommendations on treatment and follow-up. Specific techniques include surgery, postoperative MRI, radiotherapy, and chemotherapy. The primary outcome of interest is survival rate.

Anaplastic Astrocytomas and Oligodendrogliomas

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
This is a clinical practice guideline for the management and treatment of suspected or confirmed WHO grade III anaplastic astrocytomas or oligodendrogliomas in patients over 18 years of age. Comparisons are made between surgical resection and biopsy, and radiation therapy and chemotherapy are discussed as treatment options. Outcomes of interest include diagnostic accuracy, prognostic prediction, and overall survival.

Sentinel Lymph Node Biopsy and Axillary Node Dissection in Early Stage Breast Cancer

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
A clinical practice and professional guideline that seeks to establish a standard of care in Alberta for the management of axillary nodes in patients with newly diagnosed, early-stage breast cancer. The guideline compares sentinel lymph node biopsy (SLNB) with axillary lymph node dissection (ALND) for axillary staging, and provides recommendations for management of positive biopsy results. Technical and operational considerations are also discussed. Outcomes of interest include false-negative rates and survival.

Bone Health in Patients with Breast Cancer

Year: 2012
AGREE II score: Available
Developer organization: Alberta Health Services
A clinical practice guideline for breast cancer patients with bone metastases or at risk for induced bone loss. The guideline examines the use of bone-modifying agents and their administration with special considerations given to contraindicated medications and additional risk factors. Outcomes of interest include treatment efficacy, recurrence, and survival.

Non-Small Cell Lung Cancer Stage II

Year: 2011
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with stage II non-small cell lung cancer. The guideline examines diagnostic workup, treatment, and follow up for operable and inoperable patients. Outcomes of interest include improved early detection of recurrence and reduced complications through video-assisted thoracic surgery.

Non-Small Cell Lung Cancer Stage I

Year: 2011
AGREE II score: Unavailable
Developer organization: Alberta Health Services
A clinical practice guideline for patients with non-small cell lung cancer. The guideline examines diagnosis, treatment, and follow up, with a focus on surgical resection as the preferred therapy. Outcomes of interest include fewer complications through video-assisted thoracic surgery and improved control with stereotactic body radiation therapy.