Cancer Guidelines Database

Access quality cancer guidelines from a single Canadian source

We've listed 141 guidelines under your selection of "Location". The most recent guidelines are first.

Preoperative or Postoperative Therapy for the Management of Patients With Stage II or III Rectal Cancer

Year: 2019
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with clinically resectable or resected stage II or III rectal cancer. The guideline examines the appropriate preoperative staging tests and the role of postoperative radiotherapy (RT) and/or chemotherapy (CT) for patients with resected stage II or III rectal cancer. The primary outcomes of interest are increase in overall survival and delaying local recurrence.

Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline

Year: 2019
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for patients with multiple myeloma. The guideline provides recommendations for the treatment of both newly diagnosed and relapsed patients. Outcomes of interest include overall survival, progression-free survival, response rate, and quality of life.

Referral of Suspected Lung Cancer by Family Physicians and Other Primary Care Providers

Year: 2019
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients presenting to primary care services with signs and/or symptoms of lung cancer. The guideline examines the referral process for this patient population. Topics of interest include factors that have been shown to increase the risk of lung cancer, symptoms that should be present in a person before referral, indications for chest computed tomography (CT) scan, and follow-up to diagnostic investigations.

Biodegradable Rectal Spacers for Prostate Cancer Radiotherapy

Year: 2019
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients undergoing radiation treatment for localized prostate cancer. The guideline examines the use of biodegradable spacers for prostate cancer treatment. A topic of interest is biodegradable spacer insertion as a technology that may be used to decrease toxicity and maintain quality of life (QOL) in appropriately selected patients.

Three-Dimensional MR-Guided Intracavitary and Interstitial Brachytherapy for Cervical Cancer

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women with potentially curable, non-operable, locally advanced cervical cancer. The guideline provides recommendations on treatment using brachytherapy (BT), and compares different forms of BT such as two-dimensional BT, computed tomography-guided BT, magnetic resonance (MR)-guided intracavitary BT, and MR-guided intracavitary/interstitial BT. Outcomes of interest include survival, local tumour control, and toxicity.

Magnetic Resonance Imaging Screening of Women at High Risk for Breast Cancer

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women at very high risk for breast cancer. The guideline examines the effectiveness of screening using magnetic resonance imaging (MRI) in these patients, in addition to standard screening (mammography). Optimal frequency of MRI screening, subgroups that may benefit more from MRI screening, and associated harms are discussed. Workup and follow-up are also considered for those patients who have abnormal findings seen only on MRI imaging.

Sentinel Lymph Node Biopsy in Vulvar Cancer Members

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women with early-stage squamous cell vulvar cancer. The guideline examines sentinel lymph node biopsy (SLNB), including its safety and effectiveness in identifying women with node-negative, early-stage vulvar cancer. The appropriate procedures for SLNB in these patients are also discussed, such as selecting appropriate patients, determining the appropriate technique, and managing patients with positive sentinel lymph nodes.

Patient Indications for Mohs Micrographic Surgery

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on the use of Mohs micrographic surgery (MMS) for adult patients diagnosed with skin cancer. MMS is compared to other surgical excision techniques, as well as other treatment modalities such as radiation. Guidance is provided on the indications and considerations for appropriate use of MMS, including disease stage, aesthetic outcomes, patient comorbidities, and patient preferences. Outcomes of interest include cure rate, recurrence rate, quality of life, and adverse events.

The Role of High Dose Rate Brachytherapy in the Palliation of Symptoms in Patients With Non-Small Cell Lung Cancer

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with symptomatic endobronchial disease in non-small cell lung cancer. The guideline examines the use of high dose rate endobronchial brachytherapy (HDREB) for the palliation of respiratory symptoms in these patients. Specific topics discussed include the appropriate dose of HDREB, toxicity, and fatal hemoptysis.

Management of Ductal Carcinoma In Situ of the Breast

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women with ductal carcinoma in situ (DCIS) of the breast. The guideline examines the optimal surgical management of these patients, as well as radiotherapy in patients who have undergone breast-conserving surgery. The role of tamoxifen in the management of these patients is also discussed.

The Role of Primary Tumour Location in the Selection of Biologics for the Treatment of Unresectable Metastatic Colorectal Cancer: An Endorsement of a Canadian Consensus Statement

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with RAS wild-type unresectable metastatic colorectal cancer (mCRC) who are undergoing first-line or second-line chemotherapy. The guideline provides recommendations on the role of primary tumour location (PTL) in the selection of epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) and vascular endothelial growth factor (VEGF) inhibitors, in addition to chemotherapy for the treatment of unresectable mCRC.

Gallium-68 PET Imaging in Neuroendocrine Tumours

Year: 2018
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult and pediatric patients with suspected or diagnosed well-differentiated neuroendocrine tumours (NETs). The guideline discusses the clinical utility of Gallium-68 positron emission tomography (PET) compared with PET / computed tomography imaging for the initial diagnosis, staging, re-staging, response evaluation, and routine surveillance of patients with NETs.

Guideline for the Prevention of Acute Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients: A Focused Update

Year: 2017
AGREE II score: Available
Developer organization: Pediatric Oncology Group of Ontario
This is a clinical practice guideline for the prevention of acute chemotherapy-induced nausea and vomiting (CINV) in pediatric cancer patients. The guideline provides recommendations on the use of pharmacological treatments for CINV, such as aprepitant and palonosetron. Outcomes of interest include CINV control rate and adverse events.

Staging and Surgical Approaches in Gastric Cancer

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adults with Stage I to IV gastric cancer (specifically gastric adenocarcinoma) who are being considered for surgery. The guideline examines the optimal techniques to adequately stage gastric cancer, and the optimal techniques of gastric cancer surgery with curative intent. The guideline also considers indications for surgery for Stage IV gastric cancer in asymptomatic and symptomatic patients, and the relationship between surgical volumes and outcomes.

Guidance for Kyphoplasty and Vertebroplasty for Cancer Patients in Ontario: Recommendations Report 2017

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This guideline provides recommendations on use of vertebroplasty or kyphoplasty as treatment options for cancer patients with vertebral compression fractures. The guideline outlines clinical criteria for when vertebroplasty, kyphoplasty, or focal tumour ablation (FTA) assisted vertebroplasty/kyphoplasty should be performed, and provides recommendations on selecting the most appropriate procedure. The role of radiation treatment, absolute contraindications, and service provider requirements are also discussed.

Cancer Care Ontario Thyroid Cancer Guideline: An Endorsement of the 2015 American Thyroid Association Management Guidelines for Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This clinical practice guideline is an endorsement of the American Thyroid Association's 2015 guideline titled Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. The guideline provides recommendations on management of patients thyroid nodules and differentiated thyroid cancers. Topics include evaluation of thyroid nodules to determine the presence of malignancy, and management of differentiated thyroid cancer including surgery, radioactive iodine (RAI) therapy, hormonal therapy, external beam radiation therapy (EBRT), and systemic treatment.

Models of Care for Cancer Survivorship

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adults who have completed treatment and have been cured of cancer. The guideline examines different models of follow-up care, organized both by clinical setting, and by which health professionals are responsible for the coordination of care. The appropriateness of different models of care for different types of cancer is discussed, with focuses on clinical outcomes (e.g. surveillance, recurrence) and quality of life outcomes (e.g. quality of life, patient satisfaction).

Systemic Therapy for Advanced or Recurrent Endometrial Cancer and Advanced or Recurrent Uterine Papillary Serous Carcinoma

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult female patients diagnosed with advanced stage or recurrent endometrial cancer (excluding sarcomas and squamous cell carcinomas) or uterine papillary serous carcinoma. The guideline examines chemotherapeutic and hormonal therapy options for patients with these cancers. Outcomes of interest include improved response rates and survival.

Follow-up After Primary Therapy for Endometrial Cancer

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on the follow-up of patients with endometrial cancer who are clinically disease free after receiving primary treatment. The guideline reviews symptomatic signs of possible recurrence. Recommendations are provided on follow-up intervals and diagnostic interventions, stratified by risk of recurrence.

Performance of Needle Biopsy of the Prostate for Men With Suspected or Established Prostate Cancer: Recommendation Report

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This recommendation report addresses "best practices" for prostate needle biopsies. Guidance is provided on the spectrum of prostate needle biopsy practices, including patient preparation, biopsy techniques, specimen submission to the laboratory, processing of the biopsy specimen, information to include on the requisition and pathology report, and operational issues. Facility requirements are also reviewed.

Management of Primary Central Nervous System Diffuse Large B-Cell Lymphoma (PCNS DLBCL)

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical guideline for the treatment of primary central nervous system diffuse large B-cell lymphoma (PCNS DLBCL). The guideline provides recommendations regarding chemotherapy and radiation therapy and the optimal regimens, radiation dose and schedule. Outcomes of interest include overall survival, measure of disease control (response rates and progression-free survival), and frequency of adverse events.

Primary Excision Margins and Sentinel Lymph Node Biopsy in Cutaneous Melanoma

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adults diagnosed non-metastatic cutaneous melanoma, located on the trunk, extremities, or head and neck. The guideline examines optimal excision margins and the use of sentinel lymph node biopsy (SLNB) in these patients. The recommendations are organized by location of melanoma on the body, and consider the thickness/depth of the melanoma. Outcomes of interest include recurrence rate, survival rate, morbidity, and rate of sentinel lymph node positivity.

Guidance for the Management of Gynecologic Sarcomas in Ontario: Recommendations Report 2017

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This recommendations report provides guidance on the investigation and management of suspected or proven pelvic and extra-pelvic gynecologic sarcomas. Recommendations are made on the use of pathology during investigation, while recommendations pertaining to treatment focus on surgery and adjuvant therapy. The guidance document also provides recommendations on a number of quality assurance measures to assess gynecologic sarcoma services.

Referral of Patients With Suspected Colorectal Cancer by Family Physicians and Other Primary Care Providers

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on the referral of patients with signs and/or symptoms of colorectal cancer (CRC) by family physicians and other primary care providers. The guideline reviews signs, symptoms, and other clinical features that may be indicative of CRC and that warrant additional investigation. Referral wait time recommendations are provided, along with recommendations to reduce diagnostic delay. Additionally, known risk factors that increase the likelihood of CRC in patients with signs and/or symptoms of CRC are reviewed.

Treatment of Patients With Stage III (N2 or N3) Non-Small Cell Lung Cancer

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with clinical or pathological stage III non-small cell lung cancer (NSCLC). The guideline provides recommendations for the treatment of NSCLC by comparing treatment options such as chemotherapy, radiotherapy, and surgery. Outcomes of interest include adverse effects, overall survival, progression-free survival, quality of life, and local control.

Guideline for Optimization of Surgical and Pathological Quality Performance for Radical Prostatectomy in Prostate Cancer Management

Year: 2017
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult males with potentially curable prostate cancer. The guideline examines surgical procedures and outcomes for radical prostatectomy (RP), while specifically addressing the extent of resection, acceptable positive margins, nerve-sparing techniques, pelvic lymph node dissection (PLND), and the recommended procedures for handling and processing RP specimens. Incontinence, erectile dysfunction, rectal injury, and blood transfusion are discussed as surgical complications that need to be limited.

Initial Management of Small Cell Lung Cancer (Limited and Extensive Stage) and the Role of Thoracic Radiotherapy and First Line Chemotherapy

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adults with non-resected limited stage and extensive stage small cell lung cancer who can safely receive definitive radiation. The guideline examines thoracic radiotherapy and first-line chemotherapy as treatment options for these patients. The recommendations are tailored to patients' stage of cancer, and consider optimal timing of each treatment option, whether treatment should be sequential or concurrent, and appropriate dose or treatment regimen.

Role of Bone-Modifying Agents in Metastatic Breast Cancer: An American Society of Clinical Oncology-Cancer Care Ontario Focused Guideline Update

Year: 2017
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This clinical practice guideline is a focused update of the American Society of Clinical Oncology's 2016 guideline titled American Society of Clinical Oncology Clinical Practice Guideline Update: Recommendations on the Role of Bone-modifying Agents in Metastatic Breast Cancer. The guideline examines the role of bone-modifying agents (BMAs) in the treatment of patients with metastatic breast cancer, while specifically focusing on the intervals between doses of zoledronic acid, and the use of BMA's to control pain secondary to bone metastases. In addition to zolendronic acid, BMA's compared include denosumab, and pamidronate.

The Use of Targeted Therapies in Patients With Inoperable Locally Advanced or Metastatic Renal Cell Cancer: Updated Guideline 2017

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adults with inoperable locally advanced or metastatic renal cell cancer. The guideline provides recommendations on optimal targeted therapies and compares different drug treatments and combinations of treatments. Outcomes of interest include overall quality of life, overall survival, toxicity, fatigue, and other adverse events.

Systemic Therapy for Recurrent Epithelial Ovarian Cancer

Year: 2017
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women with recurrent epithelial ovarian cancer (EOC), including fallopian tube and primary peritoneal cancers. The guideline examines the most up-to-date systemic therapy treatment recommendations for recurrent EOC in order to promote evidence-based practice in Ontario. Outcomes of interest include improvements in progression-free survival and symptom control.

Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I to IIIA Completely Resected Non-Small-Cell Lung Cancers: American Society of Clinical Oncology/Cancer Care Ontario Clinical Practice Guideline Update

Year: 2017
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline discussing adjuvant therapy for adult patients with non-small cell lung cancer (NSCLC). The guideline specifically examines the appropriateness of adjuvant systemic therapy versus adjuvant radiation therapy in adults with completely resected stage I-IIIA NSCLC. Recommendations are made based on disease stage, as well as other factors such as tumour size, genetics, and histology.

Brachytherapy for Patients With Prostate Cancer: American Society of Clinical Oncology/Cancer Care Ontario Joint Guideline Update

Year: 2017
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for patients with newly diagnosed prostate cancer who require or choose active treatment, and are not receiving active surveillance by choice or lack of suitability. The guideline examines the efficacy of brachytherapy, as compared to and combined with external beam radiation therapy (EBRT) and radical prostatectomy (RP). The guideline also considers which isotopes should be used for low-dose rate (LDR) brachytherapy to maximize clinical outcomes.

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: A Cancer Care Ontario and American Society of Clinical Oncology Clinical Practice Guideline

Year: 2017
AGREE II score: Available
Developer organization: American Society of Clinical Oncology
This is a clinical practice guideline for patients with early or locally advanced (nonmetastatic) breast cancer. The guideline examines the use of bisphosphonates and other bone-modifying agents as adjuvant therapy in patients with breast cancer. Outcomes of interest include recurrence and survival, with focus on the dependency of effectiveness on age or menopausal status.

Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer

Year: 2016
AGREE II score: Available
Developer organization: Pediatric Oncology Group of Ontario
This is a clinical practice guideline for children aged 1 month to 18 years who are receiving chemotherapy. The guideline examines the management of chemotherapy-induced nausea and vomiting (CINV), including the treatment of breakthrough CINV and the prevention of refractory CINV. The primary outcome of interest is a decrease in the incidence of CINV.

The Use of Adjuvant Radiation Therapy for Curatively Resected Melanoma

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with stage 1-3 cutaneous melanoma who have received curative resection. The guideline examines the appropriateness of adjuvant radiation therapy (RT) for these patients, narrowing the focus on those patients with primary melanoma, in-transit primary melanoma, recurrent melanoma, and those at high risk for regional recurrence of melanoma. The guideline also considers whether equivalent disease control is provided with a standard fractionation schedule and a hypofractionated schedule. Outcomes of interest include control rate, survival rate and adverse event rates.

Breast Cancer Reconstruction Surgery (Immediate and Delayed) Across Ontario: Patient Indications and Appropriate Surgical Options

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women with breast cancer who have chosen or been recommended for therapeutic mastectomy, and women who are at high risk for breast cancer who have chosen or been recommended prophylactic mastectomy. The guideline considers the suitability of patients for immediate or delayed breast cancer reconstruction surgery, appropriate timing of treatment, and optimal surgical techniques. Techniques examined include skin-sparing mastectomy (SSM), nipple-sparing mastectomy (NSM) and areola-sparing mastectomy, as well as autologous tissue and implant-based reconstruction.

Interventions to Address Sexual Problems in People With Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult men and women that have sexual function side effects as a result of cancer diagnoses and/or treatment. The guideline examines strategies/interventions to manage sexual function side effects with the aim of decreasing distress, and improving quality of life for cancer survivors and their partners. Both pharmacologic and non-pharmacologic interventions are discussed.

Management of a Suspicious Adnexal Mass

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women presenting with suspicious adnexal masses, either symptomatic or asymptomatic. The guideline examines the optimal strategies for preoperative identification of adnexal masses that are suspicious for ovarian cancer, and the most appropriate surgical procedures for those identified.

Surgical Management of Patients With Lymph Node Metastases from Cutaneous Melanoma of the Trunk or Extremities

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with cutaneous melanoma of the trunk or extremities. The guideline examines the optimal surgical management of patients with positive sentinel lymph nodes (SLNs) and biopsy-proven clinically palpable or biopsy-proven radiologically detected lymph nodes from cutaneous melanoma originating in the trunk or extremities. Outcomes of interest include local and regional recurrence, distant recurrence, overall survival (OS), and disease-free survival (DFS).

Systemic Treatment for Patients With Advanced Non-Small Cell Lung Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for the treatment of advanced non-small cell lung cancer (NSCLC). The guideline examines the efficacy of different therapies including chemotherapy and immune checkpoint inhibitors. Outcomes of interest include overall survival, progression-free survival, quality of life, toxicity, and response rate.

Optimization of Surgical and Pathological Quality Performance in Radical Surgery for Colon and Rectal Cancer: Margins and Lymph Nodes

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for the staging and treatment of colorectal cancer. The guideline focuses on surgical and pathological considerations for the resection of colorectal cancer and provides recommendations on the technique and extent of resection, as well as the reporting of resection results. Outcomes of interest include overall survival, disease-free survival, recurrence rates, and margin status.

Referral of Suspected Prostate Cancer by Family Physicians and Other Primary Care Providers

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline on the diagnosis of prostate cancer. The guideline examines effective diagnostic methods and provides recommendations on testing and referrals. Outcomes of interest include diagnostic accuracy, sensitivity, and specificity. Other topics of discussion include factors associated with delayed referral and risk factors that are predictive of prostate cancer.

Systemic Therapy of Incurable Gastroenteropancreatic Neuroendocrine Tumours

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adults diagnosed with incurable gastroenteropancreatic neuroendocrine tumours. The guideline examines treatment options for pancreatic neuroendocrine tumours and non-pancreatic neuroendocrine tumours, including chemotherapy, targeted therapy, somatostatin analogues and interferon, and combination therapy. Outcomes of interest include progression-free and overall survival, adverse events, and quality of life.

Stem Cell Transplantation in the Treatment of Acute Lymphoblastic Leukemia

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for stem cell transplantation (SCT) in the treatment of acute lymphoblastic leukemia. The guideline establishes indications for allogeneic stem cell transplantation (allo-SCT) in the management of acute lymphoblastic leukemia (ALL) in adults. It identifies the role of reduced-intensity conditioning (RIC) regimens for SCT in the management of ALL adult patients, and the role of tyrosine-kinase inhibitors (TKIs) for patients undergoing allo-SCT for Philadelphia chromosome-positive ALL (Ph+ ALL). The guideline also discusses the role of alternative donor transplantation (haploidentical, cord blood) in the management of adult patients with ALL who lack a suitable donor. Outcomes of interest are relapse, disease-free survival, relapse-free survival, progression-free survival, and overall survival.

Systemic Therapy in the Curative Treatment of Head and Neck Squamous Cell Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with locally advanced nonmetastatic (stages III-IVB) squamous cell carcinoma of the head and neck (LASCCHN). The guideline examines the use of systemically administered drugs in combination or in sequence with radiation (RT), surgery, or both. Outcomes of interest include tumour response rate, survival rate, and organ preservation.

Clinical Utility of Multigene Profiling Assays in Invasive Early-Stage Breast Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women diagnosed with invasive early-stage breast cancer. The guideline discusses the use of different multigene profiling assays for determining risk profiles (high-risk vs low-risk) in patients with estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative tumours. The validity and clinical utility of different assays are examined, including Oncotype DX, Prosigna, MammaPrint, EndoPredict, and EPclin. In addition, assays are specifically compared to Oncotype DX, the only assay that was publicly funded and part of standard practice in Ontario at the time of publication.

Bone Health and Bone-Targeted Therapies for Prostate Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for men with prostate cancer who are receiving androgen deprivation therapy (ADT). The guideline examines the effectiveness of therapies that target bone, which can mitigate the effects of ADT on bone health. Outcomes of interest include fracture, bone mineral density (BMD), osteoporosis, skeletal-related events (SREs), bone metastasis, pain, patient-reported quality of life (QOL), and overall survival.

Magnetic Resonance Imaging for Pre-Treatment Local Staging of Prostate Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for magnetic resonance imaging (MRI) for pre-treatment local staging of prostate cancer. The use of MRI for pre-treatment local staging is juxtaposed with the ways in which prostate cancer is conventionally detected which includes prostate-specific antigen (PSA) screening, digital rectal examination (DRE), and biopsy-confirmed diagnosis by transrectal ultrasonography (TRUS). The guideline therefore explores the performance and diagnostic accuracy of MRI, as well as the impact of pre-treatment local staging by MRI on patient on patient outcomes, biochemical recurrence, changes in treatment planning (including nerve- sparing surgery), changes in stage classification, and surgical margin status in men with newly diagnosed biopsy-confirmed prostate cancer who are under consideration for radical treatment.

Radiotherapy with Curative Intent in Patients with Early Stage, Medically Inoperable, Non-Small Cell Lung Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with potentially curable, early stage (Stage I or II) NSCLC (without nodal involvement or metastases), and who are deemed medically inoperable or refuse surgery. The guideline provides discusses the use of stereotactic body radiation therapy (SBRT)/stereotactic ablative radiation therapy with curative intent and provides recommendations on fractionation schemes. Outcomes of interest include tumour control and survival as well as toxicity.

Adjuvant Care for Stage I Ovarian Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for women with stage I ovarian cancer. The guideline examines adjuvant therapy, primarily systemic therapies, in relation to surgical staging. Outcomes of interest include overall and disease-free survival.

Preoperative or Postoperative Therapy for Resectable Esophageal Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with clinically resectable or resected stage II or III rectal cancer. The guideline reviews the use of pre- and post-operative therapy including chemotherapy and radiotherapy as treatment options. Outcomes of interest include survival (overall, cause-specific), quality of life, acute and late toxicities, and postoperative morbidity (within 30 days of surgery).

Follow-up Care, Surveillance Protocol, and Secondary Prevention Measures for Survivors of Colorectal Cancer

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations for follow-up care, surveillance protocol, and secondary prevention measures for survivors of colorectal cancer. The guideline addresses the following questions which include: what evaluations (e.g., colonoscopy, computed tomography [CT], carcinoembryonic antigen [CEA], liver function, complete blood count [CBC], chest x-ray, history, physical exam) should be performed for surveillance for recurrence of cancer? What is a reasonable frequency of these evaluations for surveillance? Which symptoms and/or signs potentially signify a recurrence of CRC and warrant investigation?

Systemic Treatment of Acute Myeloid Leukemia (AML)

Year: 2016
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with acute myeloid leukemia (AML), excluding acute promyelocytic leukemia, who are deemed suitable for intensive treatment. The guideline includes consideration of the most effective systemic post-remission treatment - consolidation and/or maintenance - for adults with previously untreated AML. The guideline also considers which patient characteristics are most important when making treatment decisions.

Guideline for the Prevention of Oral and Oropharyngeal Mucositis in Children Receiving Treatment for Cancer or Undergoing Haematopoietic Stem Cell Transplantation

Year: 2015
AGREE II score: Available
Developer organization: Pediatric Oncology Group of Ontario
This is a clinical practice guideline for children receiving chemotherapy or undergoing hematopoietic stem call transplantation (HSCT) for cancer. The guideline examines the effectiveness of prophylactic interventions for preventing or reducing the severity of oral and oropharyngeal mucositis in these patients. Interventions considered include cryotherapy, low-level light therapy and the use of keratinocyte growth factor (KGF).

Focal Tumour Ablation in Ontario: Recommendations Report 2015

Year: 2015
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with a variety of cancers, including lung, liver, and kidney tumours, with a specific focus on patients with hepatocellular carcinoma (HCC) or liver metastases. The guideline examines the effectiveness of thermal ablation, which encompasses radiofrequency ablation (RFA) and microwave ablation, as well as transcatheter arterial chemoembolization (TACE), alone or in combination with other strategies. The guideline outlines patient clinical criteria, criteria for service providers, and system-level criteria.

Follow-up Care and Psychosocial Needs of Survivors of Prostate Cancer

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for men with prostate cancer who have received treatment with curative intent. The frequency by which prostate-specific antigen (PSA) levels should be tested in these patients is discussed, and the guideline also examines appropriate diagnostic testing techniques for instances in which biochemical (BC) recurrence occurs. The guideline also discusses psychosocial issues, sexual health, fatigue, urinary health, and bowel heath outcomes associated with prostate cancer treatment.

Adjuvant Systemic Chemotherapy for Stage II and III Colon Cancer Following Complete Resection

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline is for the treatment of patients with stage II and III colon cancer who have undergone complete resection with curative intent. The guideline examines the impact of different adjuvant chemotherapy regimens. Outcomes of interest include overall survival, disease-free survival, adverse events, and quality of life.

Effective Use of Advanced Practice Nurses in the Delivery of Adult Cancer Services in Ontario

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This guideline provides recommendations on the use of advanced practice nurses (APNs) to optimize patient, provider, and health system outcomes across the cancer care continuum. Specifically, the guideline reviews patient populations and situations (types of needs, practice settings, phase of the cancer care continuum) for which APN roles have demonstrated equivalent or improved outcomes, or reduced harms in cancer care. Outcomes of interest include quality of life, physical, functional, psychosocial, and mental health, as well as morbidity, mortality, symptom management, patient and provider satisfaction, health care utilization, costs, and quality of care.

Follow-up of Patients with Cutaneous Melanoma who were Treated with Curative Intent

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with cutaneous melanoma after treatment with curative intent. The guideline provides recommendations on follow-up schedules, involving appropriate evaluations and timing for early detection of local-regional recurrence, distant metastases, and new primary melanomas. Diagnostic imaging modalities such as ultrasound (US), computed tomography (CT), positron emission tomography (PET), and PET/CT, laboratory tests such as LDH and S100B, skin self-examinations, and dermoscopy/dermatoscopy are discussed.

Guideline for Referral of Patients with Suspected Prostate Cancer by Family Physicians and Other Primary Care Providers

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for referral of patients with suspected prostate cancer by family physicians and other primary care providers. More specifically, the guidelines provide recommendations for referral based on digital rectal examination (DRE) findings and prostate-specific antigen (PSA) test results. The research questions that guided the development of recommendations included: what signs, symptoms, and other clinical features that present in primary care are predictive of prostate cancer; what is the diagnostic accuracy of investigations commonly considered for patients presenting with signs and/or symptoms of prostate cancer; and what major, known risk factors increase the likelihood of prostate cancer in patients presenting with signs and/or symptoms of prostate cancer.

The Management of Depression in Patients with Cancer

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for cancer patients. The guideline examines the screening, diagnosis, and management of depression in patients with major depressive disorder or who have a suspected depressive disorder. Outcomes of interest include improved health outcomes and reduced adverse events.

Imatinib Mesylate (Gleevec™) for the Treatment of Adult Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumours: A Clinical Practice Guideline

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for the treatment of adult patients with unresectable or metastatic gastrointestinal stromal tumours. The guideline states that unresectable or metastatic gastrointestinal stromal tumours are often resistant to traditional methods of treatment like conventional chemotherapy. As such, the guideline focuses on the benefits and harms of imatinib mesylate as a form of treatment. The guideline therefore considers whether treatment with imatinib mesylate has a benefit in terms of tumour response, disease progression, survival or quality of life.

The Use of Systemic Treatment in the Maintenance of Patients With Non-Small Cell Lung Cancer

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on use of systemic treatment in the care of advanced, stage IIIB/IV patients who have non-small cell lung cancer (NSCLC) that has not progressed (i.e., complete response, partial response or stable disease) following four to six cycles of platinum-based chemotherapy and who have maintained an Eastern Cooperative Oncology Group performance status of 0 to 2. The guideline discusses use of pemetrexed, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), and use of maintenance chemotherapies, namely docetaxel and gemcitabine. Overall survival and quality of life were critical outcomes for the development of recommendations within this guideline.

Follow-up for Cervical Cancer

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for female patients who have received potentially curative primary treatment for cervical cancer. The guideline examines appropriate follow-up strategies including minimum levels of screening and follow-up intervals. Outcomes of interest include recurrences detected during screening and survival rates.

Multiparametric Magnetic Resonance Imaging in the Diagnosis of Clinically Significant Prostate Cancer

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for the diagnostic assessment of clinically significant prostate cancer. The guideline examines Multiparametric magnetic resonance imaging as an alternative to traditional transrectal ultrasound–guided systematic biopsy in order to reduce over- or under-diagnosis of clinical results. Outcomes of interest include detection rate of clinically significant prostate cancer, improved survival, and improved predictive value.

The Organization of Colposcopy Services in Ontario: Recommended Framework

Year: 2015
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
An organizational guideline for the provision of colonoscopies to patients with abnormal cervical screening results. The guideline examines the provision of consistent quality in colonoscopies, including training and competence, practices, and quality indicators. Important aspects include training program availability, referral criteria, and group vs. individual practice requirements.

An Organizational Guideline for Gynecologic Oncology Services

Year: 2015
AGREE II score: Unavailable
Developer organization: Gynecologic Oncology Organizational Guideline Development Group
An organizational guideline for the provisions of gynecologic oncology services by multidisciplinary professionals. The guideline examines the efficacy of specialist treatment, resource allocation, and the organization of work and services. Important aspects include the role of gynecologic oncologist, annual surgical case volumes, and minimum treatment standards.

Plerixafor for Autologous Hematopoietic Stem Cell Mobilization and Transplantation for Patients in Ontario

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for the use of plerixafor for autologous hematopoietic stem cell mobilization and transplantation in patients with hematologic cancers. The guideline examines administration with granulocyte-colony stimulating factor in patients who have or have not been mobilized before. Outcomes of interest include successful apheresis harvest, number of CD34+ cells collected, and survival rate.

Approach to Fever Assessment in Ambulatory Cancer Patients Receiving Chemotherapy

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with cancer who are receiving chemotherapy and experiencing fever, including patients with a solid tumour, lymphoma/myeloma/chronic lymphocytic leukemia, living at home, and/or with an unknown neutrophil count. This excludes hospital inpatients, patients in the emergency department, patients already diagnosed with febrile neutropenia, or with hematopoietic stem cell transplantation, acute leukemia, or myelodysplastic syndrome. The guideline provides recommendations on assessment of fever and provision of patient education. The guideline focuses on unfavourable outcomes including febrile neutropenia, infection, and death.

Imatinib Mesylate (Gleevec™) for the Treatment of Adult Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumours

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline reviews the use of imatinib in the treatment of adult patients with unresectable or metastatic gastrointestinal stromal tumours (GIST) expressing KIT (CD117+). Recommendations are provided on dosage and schedule. Outcomes of interest include overall and progression free survival, and quality of life.

Lenalidomide in Multiple Myeloma

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with multiple myeloma. The guideline reviews the use of lenalidomide as a treatment option for previously untreated or relapsed/refractory multiple myeloma as compared to non-lenalidomide treatments. Use of lenalidomide as a maintenance or consolidation treatment (following transplant and non-transplant treatments) is examined and strategies for managing toxicity are discussed. Outcomes of interest include disease progression, adverse events, safety, and overall survival.

Management of Early-Stage Hodgkin Lymphoma

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on management of early-stage Hodgkin lymphoma. Chemotherapy alone, radiation therapy alone, and chemoradiation therapy are all reviewed as potential treatment options and provides recommendations on strategy, optimum radiation doses and schedule, and chemotherapy regimes. Outcomes of interest include overall survival, other measures of disease control (e.g. event-free survival or failure-free survival), and long-term adverse events, among others.

Pan-Canadian Practice Guideline: Screening, Assessment and Management of Psychosocial Distress, Depression and Anxiety in Adults with Cancer

Year: 2015
AGREE II score: Available
Developer organization: Canadian Association of Psychosocial Oncology
A clinical practice guideline for the screening, assessment and management of psychosocial distress, depression and anxiety in adults with cancer. The guideline examines appropriate clinical intervals for psychosocial screening, contributing factors, and interdisciplinary care. Outcomes of interest include improvement in cancer-related worry and reduced post traumatic stress.

Breast Cancer Risk Reduction, Version 2.2015

Year: 2015
AGREE II score: Available
Developer organization: National Comprehensive Cancer Network
This is a clinical practice guideline for women who are at increased risk of developing breast cancer. The guideline provides an overview on risk assessment, risk-reduction interventions including lifestyle interventions, risk-reduction surgery, and risk-reduction agents (tamoxifen, raloxifene, aromatase inhibitors). Recommendations are also provided for managing side effects of risk-reduction agents and monitoring for complications. Risk-reduction counselling is also discussed.

Rituximab in Lymphoma and Chronic Lymphocytic Leukemia: A Clinical Practice Guideline, Version 3

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline discusses the use of rituximab as a treatment option for adult patients with lymphoma or chronic lymphocytic leukemia (CLL), including combination chemotherapy, rituximab monotherapy, and rituximab maintenance therapy for patients who respond to treatment with combination chemotherapy and/or rituximab. Screening for surface antigen for hepatitis B (HBsAg) and hepatitis B core antibody (HBcAb) prior to treatment with rituximab is also discussed. Outcomes of interest are overall survival, disease control (overall, progression free, failure-free, or disease free survival; response duration), response rate, quality of life, and toxicity.

Exercise for People with Cancer

Year: 2015
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on exercise for adult patients living with cancer (including those on active treatment and who have completed treatment). Benefits of specific types of exercise are considered along with safety concerns, and recommendations are provided for delivery models and exercise regimens for patients living with cancer at different points in the cancer journey, as well as pre-screening requirements for new referrals. Outcomes of interest include quality of life, safety, and muscular and aerobic fitness.

A Pan Canadian Practice Guideline for Screening, Assessment, and Management of Cancer-Related Fatigue in Adults: Version 2-2015

Year: 2015
AGREE II score: Available
Developer organization: Canadian Association of Psychosocial Oncology
This is a clinical practice guideline for the screening, assessment and management of cancer-related fatigue in adults. The guideline examines the efficacy of interventions (pharmacological, non-pharmacological, and/or combinations) for reducing cancer-related fatigue in adults and comparisons are made to usual care and attention control. Outcomes of interest include clinically significant improvement in fatigue or clinically significant reduction in cancer-related fatigue (measured by severity) or differences in fatigue severity between intervention group and controls using self-reported outcome measures.

Dose Objectives for Head and Neck IMRT Treatment Planning, Recommendation Report 2014

Year: 2014
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with head and neck cancer. The guideline examines the use of intensity modulated radiation therapy (IMRT) as a treatment method, with a particular focus on dose objectives. Recommendations are provided on dose limits and dose coverage for different regions of interest, while considering tolerance and the risk of early and late side effects.

Active Surveillance for the Management of Localized Prostate Cancer: Guideline Recommendations

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with low-risk prostate cancer. The guideline examines the role of active surveillance (AS) as a management strategy for low-risk prostate cancer patients, and aims to develop a standardized protocol to ensure that AS is offered to appropriate patients. Outcomes of interest include survival, and patient compliance.

The Use of Indoor Tanning Devices and the Risk of Developing Cutaneous Malignant Melanoma: A Systematic Review and Clinical Practice Guideline

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for patients at risk of developing melanoma due to the use of indoor tanning devices. The guideline examines risk due to use, impact of age, and frequency of use as it relates to cutaneous malignant melanoma. Outcomes of interest include relative risk and increased risk.

Use of the Epidermal Growth Factor Receptor Inhibitors Gefitinib (Iressa®), Erlotinib (Tarceva®), Afatinib, Dacomitinib or Icotinib in the Treatment of Non–Small-Cell Lung Cancer: A Clinical Practice Guideline

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This practice guideline examines the use of EGFR tyrosine kinase inhibitors (EGFR TKI) for treatment of adult patients with advanced (stage IIIB or IV) non– small-cell lung cancer. The guideline provides recommendations on the sequence of chemotherapy and EGFR TKIs is reviewed, and discusses whether clinical characteristics (i.e. Asian ethnicity, female sex, adenocarcinoma histology and light/never smoking status) or molecular characteristics (presence of activating mutations of the EGFR gene, EGFR gene copy number, or EGFR protein overexpression) should influence use of EGFR TKIs. Outcomes of interest include overall survival, progression-free survival (PFS), response rate and quality of life.

Optimization of Preoperative Assessment in Patients Diagnosed with Rectal Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with rectal cancer who are newly diagnosed. The guideline provides recommendations on investigations to assess for metastases and synchronous lesions, imaging for local staging, optimal MRI protocol and criteria for local staging, optimal MRI criteria to select patients for neoadjuvant therapy, the role of multidisciplinary cancer conferences and the role of restaging MRI after neoadjuvant therapy.

Continuous versus Intermittent Chemotherapy Strategies in Inoperable, Advanced Colorectal Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients (18 years or older) with inoperable, advanced (Stage IV) colorectal cancer. The guideline provides recommendations on the use of intermittent systemic treatment strategies. Outcomes of interest include overall response rate, survival (overall, progression-free, failure free), toxicity, and quality of life.

Strategies of Sequential Therapies in Unresectable, Metastatic Colorectal Cancer Treated With Palliative Intent

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients (18 years or older) with unresectable metastatic colorectal cancer. The guideline provides recommendations on sequential chemotherapy strategies for treatment with palliative intent. The cytotoxic agents discussed include initial fluoropyrimidine (5-FU or capecitabine) either alone or in combination, irinotecan and oxaliplatin. Outcomes of interest are overall survival, toxicity, and quality of life.

Systemic Therapy for Recurrent, Metastatic, or Persistent Cervical Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations on use of systemic therapy for women with metastatic, recurrent, or persistent cervical cancer including women with squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix. The guideline discusses use of cisplatin-paclitaxel, cisplatin-vinorelbine, cisplatin gemcitabine, and cisplatin-topotecan, and reviews the substitution of carboplatin for cisplatin in any of these combinations. Additionally, the indications for use of bevacizumab in combination with cisplatin-paclitaxel or carboplatin-paclitaxel are discussed. Primary outcomes of interest are overall survival and quality of life, with other outcomes of consideration including response rate, progression-free survival rate, and adverse effects

Optimal Systemic Therapy for Early Female Breast Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for female patients with early stage invasive breast cancer. The guideline examines systemic therapy selection based on patient and disease characteristics, and recurrence risk. Outcomes of interest include breast cancer-free intervals, disease-free survival, and clinically complete response.

Sentinel Lymph Node Biopsy in Vulvar Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline provides recommendations in relation to sentinel lymph node biopsy (SLNB) in vulvar cancer. The guideline seeks to determine whether SLNB can safely and effectively identify women with node-negative, early-stage vulvar cancer and can be used as an alternative to inguinofemoral lymph node dissection (IFLD). Additionally, the guideline provides guidance with respect to the appropriate techniques and procedures in SLNB for women with early-stage vulvar cancer. These include: the selection of appropriate patients; determining the appropriate technique, and management of patients with positive sentinel lymph nodes.

Locoregional Therapy of Locally Advanced Breast Cancer (LABC)

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for the treatment of female patients with locally advanced breast cancer. The guideline includes consideration of the role of breast-conserving surgery as compared with mastectomy. Other important aspects explored in the guideline include the role of radiotherapy following a mastectomy, as well as the treatment options for those female patients with locally advanced breast cancer who do not respond to initial neoadjuvant therapy.

Follow-up and Surveillance of Curatively Treated Lung Cancer Patients

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for patients with small cell and non-small cell lung cancer who have undergone curative treatment. The guideline examines screening and disease control through imaging and follow-up visits to prevent recurrence. Outcomes of interest include increased follow-up recommendations for the first two years after treatment, when recurrence is most likely to occur.

Sunitinib Malate for Gastrointestinal Stromal Tumour (GIST) in Imatinib Mesylate Resistant Patients

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with unresectable or metastatic/recurrent gastrointestinal stromal tumours that have become resistant or intolerant to imatinib mesylate. The guideline examines the efficacy of sunitinib malate as an alternative, and reviews what dosing regimens could be observed. Outcomes of interest include partial response, but no difference in quality of life.

The Management of Thymoma: A Systematic Review and Practice Guideline

Year: 2014
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with locally advanced, unresectable, and recurrent thymoma. The guideline examines treatment options, primarily surgical resection, as well as preferred approaches to therapy. Outcomes of interest include ranged overall survival, and improved recommendations for patients medically unfit for surgery.

Alemtuzumab in Chronic Lymphocytic Leukemia

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with chronic lymphocytic leukemia (CLL). This guideline examines the use of alemtuzumab, and its associated adverse treatment-related toxicities. Although no definitive data on quality of life or overall survival was identified, case-series studies suggest alemtuzumab could still be a reasonable option for patients with progressive and symptomatic CLL.

Systemic Therapy for Advanced or Recurrent Endometrial Cancer, and Advanced or Recurrent Uterine Papillary Serous Carcinoma

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with advanced stage or recurrent endometrial cancer. The guideline examines the use of chemotherapy, specifically combination chemotherapy, and hormonal therapy with a specific focus on the use of cisplatin, doxorubicin, and paclitaxel. Outcomes of interest include reduced adverse effects, and improvements in progression-free survival and overall survival.

Management of Stage I Seminoma

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with stage 1 testicular seminoma. The guideline outlines treatment options including radiotherapy and chemotherapy, and provides recommendations on follow-up surveillance. Outcomes of interest include cancer-specific survival, long-term toxicity (including second malignancy), and quality of life.

Adjuvant Radiotherapy Following Radical Prostatectomy for Pathologic T3 or Margin-Positive Prostate Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for male patients who have undergone radical prostatectomy for clinically localized prostate cancer and who have been found to have either positive surgical resection margins (R1), tumour extension beyond the prostatic capsule (pT3a), seminal vesicle invasion (pT3b), or more than one of these features. The guideline provides recommendations on the use of adjuvant radiotherapy following radical prostatectomy. Outcomes of interest include survival (prostate cancer-specific, metastasis-free, biochemical progression-free, and locoregional recurrence-free), time to initiation of androgen deprivation therapy, toxicity (acute and late), and quality of life.

Systemic Therapy for Advanced Gastric Cancer

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with advanced (non-resectable; either locally advanced or metastatic) adenocarcinoma of the gastroesophageal junction (but not with squamous cell carcinoma). The guideline provides recommendations on chemotherapy treatment with review of chemotherapy agents by class, as well as comparison of 5-fluorouracil (CIV)/epirubicin/cisplatin regimens vs. other chemotherapy. The guideline also discusses the contribution of targeted therapies. Outcomes of interest including overall survival, objective response rate (complete plus partial response), time to disease progression, adverse effects, and quality of life.

Safe Administration of Systemic Cancer Therapy Part 2: Administration of Chemotherapy and Management of Preventable Adverse Events

Year: 2014
AGREE II score: Available
Developer organization: Cancer Care Ontario
A practice and professional guideline for the safe administration of systemic therapies, specifically chemotherapy, to patients by organizations that provide systemic cancer treatment. The guideline examines the appropriate selection of devices for vascular access, complications factors based on points of care, and recommended nursing practices. Key aspects include reducing fatal outcomes and improved organizational safety policies.

Guideline for the Prevention and Treatment of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients

Year: 2014
AGREE II score: Available
Developer organization: Pediatric Oncology Group of Ontario
A clinical practice guideline for adult and pediatric patients undergoing chemotherapy for cancer. The guideline examines the prevention and treatment of chemotherapy induced nausea and vomiting through both psychosocial and pharmacological interventions. Outcomes of interest include moderate improvement with minimal risk through non-pharmacological means, and reduction of negative stimuli.

Guideline for Colonoscopy Quality Assurance in Ontario

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A professional guideline for colonoscopy training as part of fecal occult blood test based colorectal cancer screening. The guideline examines training, competency maintenance, and quality assurance measures for colonoscopies and related patient assessment procedures. Outcomes of interest include improved auditable outcomes and clearer pre-assessment standards.

Safe Handling of Cytotoxics

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A professional guideline for health-care workers who may come into contact with cytotoxic drugs. The guideline examines safety measures, with particular attention paid to protective equipment, receiving, transport, and preparation. Outcomes of interest include reduced risk for pregnant workers and improved closed-system handling.

Liposomal Anthracyclines in the Management of Patients with HIV-Positive Kaposi’s Sarcoma

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for patients with HIV-positive Kaposi’s sarcoma. The guideline examines the use of liposomal anthracycline therapy in aggressive cutaneous or visceral disease sites and comparisons are made to combination chemotherapy. Outcomes of interest include no significant differences between liposomal therapy and conventional combination therapy.

Optimal Treatment Options and Follow-up Strategies in Patients with Desmoid Tumours

Year: 2013
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A clinical practice guideline for patients with desmoid tumours who are either pursuing active treatment or have already received primary treatment. The guideline examines treatment and follow-up strategies, including recommendations for multiple concurrent treatment options and appropriate rehabilitation. Outcomes of interest include lack of statistically significant information for optimal treatment choice, and increased focus on multidisciplinary sarcoma teams.

Systemic Adjuvant Therapy for Patient at High Risk for Recurrent Melanoma

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with resected melanoma at high risk for recurrence. The guideline examines systemic therapy options, specifically with interferon, and highlights the importance of novel therapeutic trials. Outcomes of interest include improved melanoma staging and improved event-free survival.

The Role of High Dose Rate Brachytherapy in the Palliation of Symptom in Patients with Non-Small Cell Lung Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with symptomatic endobronchial disease in non-small cell lung cancer. The guideline examines the use of high dose rate endobronchial brachytherapy for respiratory symptoms. Outcomes of interest include improved local control with combined therapies, and no increased toxicity complications.

The Role of Photodynamic Therapy in Patients With Non-Small Cell Lung Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with primary, non-small cell lung tumours. The guideline examines the use of photodynamic therapy in treatment and palliative care, and comparisons are made to traditional radiotherapy. Outcomes of interest include improved tumour response rates and reduced treatment failures in late stage lung cancer.

Altered Fractionation of Radical Radiation Therapy in the Management of Unresectable Non-Small Cell Lung Cancer

Year: 2013
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A clinical practice guideline for patients with locally advanced, unresectable stage III non-small cell lung cancer. The guideline examines radical radiation therapy, specifically continuous hyperfractionated accelerated radiation therapy, in comparison to traditional radiotherapy. Outcomes of interest include a improved survival benefit over radiotherapy and improved control rates.

Use of Preoperative Chemotherapy With or Without Postoperative Radiotherapy in Technically Resectable Stage IIIA Non-Small Cell Lung Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for patients with technically resectable stage IIIA non-small cell lung cancer. The guideline examines the use of preoperative chemotherapy in conjunction with, or instead of, radiotherapy. Outcomes of interest include improved survival rates with no significant increases in toxicity.

The Use of Chemotherapy and Growth Factors in Older Patients with Newly Diagnosed, Advanced-Stage, Aggressive Histology Non-Hodgkin’s Lymphoma

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients over the age of 60, with newly diagnosed, advanced-stage, aggressive histology non-Hodgkin’s lymphoma. The guideline examines optimal treatment for this patient group, particularly with the use of granulocyte-colony stimulating factor and combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone. Outcomes of interest include a reduction in infection risk and risk of severe neutropenia.

Chemotherapy with Radiotherapy for Nasopharyngeal Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with newly diagnosed locally advanced squamous cell or undifferentiated nasopharyngeal cancer. The guideline examines treatment through the addition of chemotherapy to the recommended radiotherapy treatment. Outcomes of interest include significant differences in local control and improved progression-free survival.

Preoperative or Postoperative Therapy for Resectable Esophageal Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with resectable, operable, and potentially curable thoracic (lower two thirds of esophagus) esophageal cancer for whom surgery is considered appropriate. The guideline compares treatment regimes including pre- and postoperative chemotherapy and/or radiotherapy versus surgery alone. Outcomes of interest include treatment related mortality, local control, survival benefits, and adverse effects.

Chemotherapy or Radiotherapy for Resectable Pancreatic Adenocarcinoma

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with resectable pancreatic adenocarcinoma for whom a pancreatectomy is planned. The guideline reviews pre- and post-operative treatment options including radiotherapy and chemotherapy. Outcomes of interest include overall survival, quality of life, and adverse effects.

Preoperative or Postoperative Therapy for the Management of Patients with Stage II or III Rectal Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with clinically resectable or resected stage II or III rectal cancer. The guideline reviews the use of pre- and post-operative therapy including chemotherapy and radiotherapy as treatment options. Outcomes of interest include survival (overall, cause-specific), quality of life, acute and late toxicities, and postoperative morbidity (within 30 days of surgery).

Management of Squamous Cell Cancer of the Anal Canal

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with a primary diagnosis of biopsy-proven squamous cell cancer of the anal canal, including basaloid, cloacogenic, and transitional cell tumours. The guideline reviews treatment and follow-up care for squamous cell cancer, with radiotherapy and chemotherapy discussed as treatment options. Outcomes of interest include colostomy rate, local failure, survival, adverse effects (acute and late), and quality of life.

Bortezomib in Multiple Myeloma and Lymphoma

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with multiple myeloma or lymphoma. The guideline examines the efficacy of bortezomib as a single-agent or combination therapy. Outcomes of interest include improved time to progression and improved outcomes for relapsing patients.

Routine HPV Testing in Head and Neck Squamous Cell Carcinoma

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with head and neck squamous cell carcinoma. The guideline examines routine testing for human papilloma virus status and its appropriateness for these patients. Outcomes of interest include improved recognition of human papilloma virus status, resulting in improved overall survival.

Screening High-Risk Populations for Lung Cancer

Year: 2013
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline on the screening of high-risk patients for lung cancer using LDCT scanning. Risk factors are reviewed and recommendations are provided for duration and interval of screening. The guideline also discusses positive results and appropriate follow-up procedures. Outcomes of interest include effectiveness of screening, false positive rate, complication rate, and risk of death from radiation exposure.

Magnetic Resonance Imaging Screening of Women at High Risk for Breast Cancer

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for women at very high risk of breast cancer, with 'very high risk' defined as: a known mutation in BRCA1, BRCA2 or other gene predisposing to a markedly elevated breast cancer risk; an untested first-degree relative of a carrier of such a gene mutation; family history consistent with a hereditary breast cancer syndrome and estimated personal lifetime cancer risk >25%; a high-risk marker on prior biopsy (atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ [LCIS]); and/or radiation therapy to chest (before age 30 and at least eight years previous). The guideline discusses the use of magnetic resonance imaging (MRI) in conjunction with standard screening (mammography). Outcomes of interest include sensitivity, specificity, positive or negative predictive value, accuracy, time to diagnosis, tumour stage information (size, proportion DCIS, etc.), or improvement in patient outcome (response or survival).

Surgical Management of Malignant Pleural Mesothelioma

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with diffuse or localized malignant pleural mesothelioma. The guideline examines surgical management, including adjuvant therapies. Outcomes of interest include improved survival times for small, epithelial-type, node-negative pleural mesotheliomas and limited evidence for surgical intervention.

The Use of Chemotherapy in Patients With Advanced Malignant Pleural Mesothelioma

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with advanced, symptomatic malignant pleural mesothelioma who have a good performance status and are not suitable for surgical resection. The guideline discusses the use of chemotherapy as palliative treatment, and provides recommendations on choice of chemotherapy agent(s), dosage, and schedule. Outcomes of interest include survival, quality of life, symptom control, and response rates.

18-Fluorodeoxyglucose Positron Emission Tomography in the Diagnosis and Staging of Lung Cancer

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for the use of positron emission tomography PET scans in patients in adult patients with lung cancer. The guideline examines the use of PET scans in the diagnosis and staging of solitary pulmonary nodules, small-cell lung cancer and non-small-cell lung cancer. Outcomes of interest include imaging accuracy and the impact of new PET scan technologies.

The Role of Combination Chemotherapy in the Initial Management of Limited-Stage Small-Cell Lung Cancer

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with limited-stage small-cell carcinoma of the lung. The guideline provides recommendations on optimal combination chemotherapy regime, administration schedule, and therapy duration for first line treatment. Etoposide-cisplatin and cyclophosphamide- doxorubicin-vincristine are reviewed as combined-modality therapies. Outcomes of interest are survival and adverse effects.

Appropriate Surgical Margins and Proper Handling of Soft Tissue Sarcoma of the Extremities

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for patients with soft tissue sarcoma of the extremities and who are candidates for limb-sparing surgery. The guideline examines surgical margins for limb salvage surgery and margins for surgery in combination with chemotherapy and/or radiation. Outcomes of interest include clearer surgical margins and improved radiation treatment margins.

Chemotherapy for Relapsed Small Cell Lung Cancer

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
A clinical practice guideline for adult patients with relapsed small-cell lung cancer. The guideline examines single-agent and combination chemotherapy to improve survival and quality of life. Outcomes of interest include improved second-line treatment options, but no standard protocol.

PET Evidence from Primary Studies and Systematic Reviews and Recommendations from Clinical Practice Guidelines January to June 2011

Year: 2012
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A clinical practice guideline summarizing the use of positron emission tomography (PET) in the diagnosis, staging, and treatment of patients with cancer. The guideline provides literature updates on PET use for multiple types of cancer. Outcomes of interest include recurrence times and safety outcomes.

Stem Cell Transplantation in Lymphoma

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline on the use of stem cell transplantation as a treatment for lymphoma in adult patients. The report provides recommendations for treatment of the following lymphomas: Hodgkin's, non-Hodgkin's, follicular, Burkitt's, and Mantle Cell. Outcomes of interest include survival, neutrophil engraftment, graft-versus-host disease, and treatment-related mortality.

Models of Care for Cancer Survivorship

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adults without evidence of disease after primary, curative treatment for any stage of cancer. The guideline reviews models of care for cancer survivorship and looks at whether certain models are favoured for specific cancer types. Outcomes of interest include disease-free survival, mortality (cancer-related and all cause), morbidity (late effects), time to recurrence, quality of life, and patient satisfaction.

Computerized Prescriber Order Entry (CPOE) for Systemic Treatment: Best Practice Guideline

Year: 2012
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This best practice guideline outlines the use of Computerized Prescriber Order Entry for Systemic Treatment (ST CPOE) systems to support the safe delivery of chemotherapy in an outpatient setting. The guideline provides recommendations to guide the design, selection, implementation, and/or evaluation of an ST CPOE system. Key topics include clinical and decision support, information and technology standards, and measurement plans.

Safe Administration of Systemic Cancer Therapy Part 1: Safety During Chemotherapy Ordering, Transcribing, Dispensing, and Patient Identification

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is part 1 of a 4 part evidence based series on the safe administration of chemotherapy to adult patients in hospital settings. Topics of discussion include pre-treatment planning, prescribing, scheduling, pharmacy preparation, and chemotherapy administration. Primary outcomes of interest are medication error rates.

The Role of Liver Resection in Colorectal Cancer Metastases

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline reviews surgical management of patients with liver metastases from colorectal cancer who have had or will have a complete resection of the primary cancer, and who meet the surgical criteria for the resection of liver-only metastases. The guideline examines the role of liver resection in special cases of liver plus extrahepatic metastases (EHM). The use of perioperative chemotherapy is also discussed. Outcomes of interest include median survival, three- and five-year survival, recurrence rate, postoperative complications, and chemotherapy-related hepatic injury.

Referral of Patients with Suspected Colorectal Cancer by Family Physicians and Other Primary Care Providers

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical guideline examines the management of adult patients presenting in primary care settings with signs and/or symptoms of colorectal cancer. Clinical presentation (focused history and physical examination), referral, and recommendations to reduce diagnostic delay are discussed. Assessment techniques include digital rectal examination, physical examination, complete blood count (CBC), fecal occult blood test (FOBT), computed tomographic (CT) colonography and double-contrast barium enema (DCBE). Outcomes of interest are positive predictive values for colorectal cancer.

Referral of Suspected Prostate Cancer by Family Physicians and Other Primary Care Providers

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical guideline examines the management of adult male patients presenting in primary care settings with signs or symptoms of prostate cancer. Management of patients presenting with unexplained symptoms of metastatic cancer, lower urinary tract symptoms (LUTS), or incidental PSA (defined as results not ordered by the attending family physician/primary care provider), are discussed. Assessment techniques include digital rectal examination (DRE), PSA tests, and prostate cancer nomograms.

Chemotherapy (i.e., Gemcitabine, Docetaxel Plus Gemcitabine, Doxorubicin, or Trabectedin) for Inoperable, Locally Advanced, Recurrent, or Metastatic Uterine Leiomyosarcoma

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline discusses the use of chemotherapy for the treatment of locally advanced, recurrent, or metastatic uterine leiomyosarcoma (LMS) in adult women. Gemcitabine, docetaxel plus gemcitabine, doxorubicin, and trabectedin are compared, and the use of granulocyte growth factor (G-CSF) is considered. Outcomes of interest include overall and progression-free survival time, tumour response rate, stable disease rate, progressive disease rate, and toxicity.

Appropriate Surgical Margins and Proper Handling of Soft Tissue Sarcoma of the Extremities

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This clinical practice guideline discusses limb-sparing surgery as a treatment for eligible patients with soft tissue sarcoma of the extremities. Adequate margins, appropriate number of surgical resection specimens, and appropriate handling techniques of specimens are examined. The appropriate use of pre- and post-operative radiotherapy is also discussed. Outcomes of interest include recurrent free survival and overall survival.

Lenalidomide in Multiple Myeloma

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult patients with multiple myeloma. The guideline reviews the use of lenalidomide as a treatment option for previously untreated or relapsed/refractory multiple myeloma as compared to non-lenalidomide treatments. Use of lenalidomide as a maintenance or consolidation treatment (following transplant and non-transplant treatments) is examined and strategies for managing toxicity are discussed. Outcomes of interest include disease progression, adverse events, safety, and overall survival.

Risk Reduction of Prostate Cancer with Drugs or Nutritional Supplements

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for adult males 18 years of age or older who are being assessed and monitored for prostate cancer. The guideline examines the effectiveness of drugs or nutritional supplements in reducing risk of prostate cancer and prostate cancer-related death in patients without prostate cancer. Outcomes of interest include prostate cancer incidence and risk, mortality, and adverse effects of treatment.

Low-Dose Rate Brachytherapy for Patients with Low- or Intermediate-Risk Prostate Cancer

Year: 2012
AGREE II score: Available
Developer organization: Cancer Care Ontario
This is a clinical practice guideline for patients with newly diagnosed low- or intermediate-risk prostate cancer who require or choose active treatment and are not considering or are not suitable for active surveillance. The guideline discusses treatment of prostate cancer with low-dose rate brachytherapy (LDR-BT), and comparisons of LDR-BT treatment alone are made to external beam therapy (EBRT) alone, radical prostatectomy (RP) alone, and LDR-BT combined with EBRT. Different isotope options for LDR-BT are also discussed. Outcomes of interest include biochemical relapse-free and overall survival, prostate cancer-specific and overall mortality, negative biopsy rate, salvage treatment rate, toxicity, and quality of life.

Guideline for the Prevention of Acute Nausea and Vomiting due to Antineoplastic Medication in Pediatric Cancer Patients

Year: 2012
AGREE II score: Available
Developer organization: Pediatric Oncology Group of Ontario
This is a guideline for pediatric patients age 1 month to 18 years who are receiving antineoplastic medication and who are at risk of experiencing antineoplastic-induced nausea and vomiting (AINV). The guideline examines methods for the prevention and optimal control of acute AINV. Recommendations for pharmacological interventions are provided based on emetic risk, and the use of adjunctive, non-pharmacological interventions is discussed. Primary outcomes of interest are therapeutic efficacy and safety.

PET Six-Month Monitoring Report 2010-2: Evidence from Primary Studies and Systematic Reviews and Recommendations from Clinical Practice Guidelines July to December 2010

Year: 2011
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A clinical practice guideline for the use of positron emission tomography (PET) in the diagnosis, staging, and treatment of patients with cancer. This guideline provides an updated literature review for multiple adult cancers. Outcomes of interest include recurrence and safety outcomes.

The Use of Cabazitaxel in Men with Castrate Resistant Metastatic Prostate Cancer Previously Treated with Docetaxel

Year: 2011
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
This special advice report reviews the use of cabazitaxel, either alone or in combination, as a treatment for adult patients with castrate resistant metastatic prostate cancer who have been previously treated with a docetaxel-containing regimen. Outcomes of interest include treatment efficacy and adverse events.

Oncology Nursing Documentation Competencies

Year: 2008
AGREE II score: Unavailable
Developer organization: Cancer Care Ontario
A professional guideline for oncology nursing competencies. The guideline examines guiding principles for nurses throughout the cancer continuum, and enumerates core competencies. Important aspects include both clinical and supportive competencies, and a focus on accountability and quality improvement.