Guideline for the Management of Fever and Neutropenia in Children with Cancer and/or Undergoing Hematopoietic Stem Cell Transplantation

This is a clinical guideline for children and adolescents with cancer and/or undergoing hematopoietic stem cell transplantation who have fever and neutropenia (FN). The guideline discusses management of FN, including risk stratification schemas, diagnostic techniques, and treatment strategies for high- and low-risk cases. Risk assessment, diagnosis, and treatment of invasive fungal disease are also discussed. Outcomes of interest include death, serious medical complications, secondary syndromes, infections, toxicity, clinical deterioration, and resolution of FN with and without modification of therapy.