This is a clinical practice guideline for patients with small cell lung cancer (SCLC). Diagnostic and staging procedures are reviewed and recommendations are provided for treatment depending on stage. Treatment options include platinum-based chemotherapy with or without concurrent accelerated hyperfractionated radiation therapy, prophylactic cranial irradiation (PCI), consolidative thoracic radiotherapy (TRT), and single-agent chemotherapy. The guideline also discusses management of elderly patients based on performance status. Outcomes of interest include survival (median, overall, and progression-free), performance status, response rate, and toxicity.