Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline

A clinical practice guideline for systemic therapy treatments in patients with human epidermal growth factor receptor 2 (HER2) –positive advanced breast cancer. The guideline examines optimal first, second, and third line treatments based on progression and the presence of other receptor-positive diseases. Outcomes of interest include improved follow up, survival and toxicity profiles.