Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: American Society of Clinical Oncology Clinical Practice Guideline

A clinical practice guideline for managing brain metastases in patients with human epidermal growth factor receptor 2 (HER2) –positive advanced breast cancer. The guideline examines local and systemic therapy treatment options based on prognosis and disease progression. Outcomes of interest include improved brain control and reduced risk of local recurrence.