Systemic Therapy for Unresectable Stage III or Metastatic Cutaneous Melanoma

A clinical practice guideline for adult patients with metastatic or unresectable stage III melanoma with possible metastatic sites in distant skin, lymph nodes, liver, lungs, bone, and the brain. The guideline examines appropriate systemic therapies and dosing regimens for first- and second-line treatments. Outcomes of interest include improved survival outcomes and increased efficacy of combination therapies.