Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

This is a clinical practice guideline for patients requiring fluoropyrimidine chemotherapy. The guideline reviews the use of clinical DPYD genotype test results to guide dosing of fluoropyrimidines (5-fluorouracil, capecitabine, and tegafur). Outcomes of interest include treatment efficacy and treatment related adverse events such as toxicity.