The Use of Chemotherapy and Growth Factors in Older Patients with Newly Diagnosed, Advanced-Stage, Aggressive Histology Non-Hodgkin’s Lymphoma

A clinical practice guideline for adult patients over the age of 60, with newly diagnosed, advanced-stage, aggressive histology non-Hodgkin’s lymphoma. The guideline examines optimal treatment for this patient group, particularly with the use of granulocyte-colony stimulating factor and combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone. Outcomes of interest include a reduction in infection risk and risk of severe neutropenia.