ECIL Recommendations for the Use of Biological Markers for the Diagnosis of Invasive Fungal Diseases in Leukemic Patients and Hematopoietic SCT Recipients

This is a clinical practice guideline for adult patients who have leukemia and/or are hematopoietic stem cell transplant recipients. The guideline provides recommendations on the use of biological tests to screen for invasive fungal diseases including invasive aspergillosis (IA), invasive candidiasis (IC), and cryptococcosis. Galactomannan (GM), b-glucan (BG), Cryptococcus Ag, mannan (Mn) Ag/anti-mannan (A-Mn) Ab, and PCR are examined as potential screening tests. Outcomes of interest include sensitivity, specificity, and positive and negative predictive values.