Treatment of Cervical Intraepithelial Neoplasia 2–3 and Adenocarcinoma In Situ: Cryotherapy, Large Loop Excision of the Transformation Zone, and Cold Knife Conization

This is a clinical practice guideline for women with histologically confirmed CIN2+ or adenocarcinoma in situ (AIS) . The guideline reviews treatment options including cryotherapy, loop electrosurgical excision procedure (LEEP)/large loop excision of the transformation zone (LLETZ), and cold knife conization (CKC). Outcomes of interest include residual/recurrent CIN2+ after treatment, and treatment complications/risks including damage to other organs, major bleeding, and minor bleeding, maternal death, HPV-negative status, premature delivery, fetal/neonatal spontaneous abortions, pelvic inflammatory disease, and inflammatory disease.