The Role of Neuropathology in the Management of Progressive Glioblastoma: A Systematic Review and Evidence-based Clinical Practice Guideline

This is a clinical practice guideline for adult patients with progressive glioblastoma. The guideline reviews diagnostic criteria and provides recommendations on techniques and ancillary studies that are most useful in separating malignant progression from treatment effect. Outcomes of interest include sensitivity, specificity, positive and negative predictive value, accuracy, and likelihood ratio of a positive and negative result.