The Role of Cytoreductive Surgery in the Management of Progressive Glioblastoma: A Systematic Review and Evidence-based Clinical Practice Guideline

This guideline reviews the use and appropriateness of repeat surgical resection for adult patients with previously diagnosed malignant glioma who are suspected of experiencing progression of the neoplastic process and are amenable to surgical resection. Outcomes of interest include survival (median), operative morbidity, postoperative mortality, prognostic factors, and quality of life.