The Role of Cytotoxic Chemotherapy in the Management of Progressive Glioblastoma: A Systematic Review and Evidence-based Clinical Practice Guideline

This clinical practice guideline reviews the use of cytotoxic chemotherapy in the management of progressive glioblastoma in adult patients. Comparisons are made among a variety of single- and multi-agent therapies. Outcomes of interest include toxicity, survival (median, overall, and 6 month), response rate, tumour control, and quality of life.