The Role of Targeted Therapies in the Management of Progressive Glioblastoma: A Systematic Review and Evidence-based Clinical Practice Guideline

This is a clinical practice guideline for the use of targeted medical therapies in the management of progressive glioblastoma in adult patients. The guideline reviews single- and multi-agent antiangiogenic therapies and targeted therapy based on specific molecules or signaling pathways. Outcomes of interest include survival (median, overall, progression free), quality of life, toxicity, and mortality.