The Role of Combination Chemotherapy in the Initial Management of Limited-Stage Small-Cell Lung Cancer

This is a clinical practice guideline for adult patients with limited-stage small-cell carcinoma of the lung. The guideline provides recommendations on optimal combination chemotherapy regime, administration schedule, and therapy duration for first line treatment. Etoposide-cisplatin and cyclophosphamide- doxorubicin-vincristine are reviewed as combined-modality therapies. Outcomes of interest are survival and adverse effects.