Use of the Epidermal Growth Factor Receptor Inhibitors Gefitinib (Iressa®), Erlotinib (Tarceva®), Afatinib, Dacomitinib or Icotinib in the Treatment of Non–Small-Cell Lung Cancer: A Clinical Practice Guideline

This practice guideline examines the use of EGFR tyrosine kinase inhibitors (EGFR TKI) for treatment of adult patients with advanced (stage IIIB or IV) non– small-cell lung cancer. The guideline provides recommendations on the sequence of chemotherapy and EGFR TKIs is reviewed, and discusses whether clinical characteristics (i.e. Asian ethnicity, female sex, adenocarcinoma histology and light/never smoking status) or molecular characteristics (presence of activating mutations of the EGFR gene, EGFR gene copy number, or EGFR protein overexpression) should influence use of EGFR TKIs. Outcomes of interest include overall survival, progression-free survival (PFS), response rate and quality of life.