First-Line Palliative Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma With Cetuximab, Platinum, and 5 FU

This practice guideline reviews first-line palliative treatment for patients with recurrent or metastatic head and neck squamous cell carcinoma. The use of cisplatin with 5-fluorouracil with or without cetuximab is compared, and recommendations are provided for treatment regimen, laboratory tests (baseline, weekly, and per cycle), clinical considerations, and assessment of treatment response. Dose modifications are also discussed.