This is a clinical practice guideline for patients with soft tissue sarcoma (STS). The guideline examines the diagnosis and treatment of these patients. Diagnostic techniques discussed include local staging, distant staging, biopsy, and pathology and molecular pathology. Treatment methods discussed include surgery, radiotherapy, adjuvant chemotherapy, neoadjuvant chemotherapy, isolated limb perfusion, as well as chemotherapy and targeted agents. Therapeutic considerations for specific STS subtypes are also examined.